Clinical & Experimental Metastasis

, Volume 25, Issue 4, pp 335–344

Selectins and selectin ligands in extravasation of cancer cells and organ selectivity of metastasis

  • Stéphanie Gout
  • Pierre-Luc Tremblay
  • Jacques Huot
Research Paper

Abstract

Metastatic spreading is a dreadful complication of neoplastic diseases that is responsible for most deaths due to cancer. It consists in the formation of secondary neoplasms from cancer cells that have detached from the primary site. The formation of these secondary sites is not random and several clinical observations indicate that the metastatic colonization exhibits organ selectivity. This organ tropism relies mostly on the complementary adhesive interactions between the cancer cells and their microenvironment. In particular, several lines of evidence suggest that the organ selectivity of colon cancer cells for the liver involves the binding of the circulating cancer cells to endothelial E-selectin. The aim of this review is to make an integrative up-date of the mechanisms that govern the organ selectivity of the metastatic process focusing more especially on the role of selectins and selectin ligands.

Keywords

Adhesion Extravasation Homing Selectins Selectin ligands Glycosylation Metastasis 

Abbreviations

CRP

Complement regulatory protein

DR3

Death receptor 3

ERK

Extracellular signal-regulated kinase

MLC

Myosin light chain

TNF

Tumor necrosis factor

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Copyright information

© Springer Science + Business Media B.V. 2007

Authors and Affiliations

  • Stéphanie Gout
    • 1
  • Pierre-Luc Tremblay
    • 1
  • Jacques Huot
    • 1
  1. 1.Le Centre de recherche en cancérologie de l’Université Laval, L’Hôtel-Dieu de QuébecQuebecCanada

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