Clinical & Experimental Metastasis

, Volume 23, Issue 2, pp 97–105

Invadopodia: Specialized Cell Structures for Cancer Invasion

Review

DOI: 10.1007/s10585-006-9014-1

Cite this article as:
Weaver, A.M. Clin Exp Metastasis (2006) 23: 97. doi:10.1007/s10585-006-9014-1

Abstract

The spread of cancer cells to distant sites in the body is the major cause of cancer patient death. Growing evidence connects specialized subcellular structures, invadopodia, to cancer invasion and metastasis. Invadopodia, or invasive foot processes, are actin-rich protrusions that localize matrix-degrading activity to cell-substratum contact points and represent sites where cell signaling, proteolytic, adhesive, cytoskeletal, and membrane trafficking pathways physically converge. Understanding how invadopodia form and function should aid in the identification of novel targets for anti-invasive therapy.

Keywords

Invadopodia Podosome Metastasis Invasion Src kinase Cell structure Actin assembly Cancer 

Abbreviations

ADAM

a disintegrin and metalloproteinase

ECM

extracellular matrix

ERK

extracellular signal-regulated kinase

FAK

focal adhesion kinase

MMP

matrix metalloproteinase

N-WASp

Neural Wiskott-Aldrich Syndrome Protein

Tks5/FISH

Tyrosine kinase substrate 5/Five SH3 domains

WASp

Wiskott-Aldrich Syndrome Protein

WAVE

WASp-family Verprolin-homologous protein

Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  1. 1.Departments of Cancer Biology and PathologyVanderbilt University Medical CenterNashvilleUSA

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