Downscaling reveals diverse effects of anthropogenic climate warming on the potential for local environments to support malaria transmission
The potential impact of climate warming on patterns of malaria transmission has been the subject of keen scientific and policy debate. Standard climate models (GCMs) characterize climate change at relatively coarse spatial and temporal scales. However, malaria parasites and the mosquito vectors respond to diurnal variations in conditions at very local scales. Here we bridge this gap by downscaling a series of GCMs to provide high-resolution temperature data for four different sites and show that although outputs from both the GCM and the downscaled models predict diverse but qualitatively similar effects of warming on the potential for adult mosquitoes to transmit malaria, the predicted magnitude of change differs markedly between the different model approaches. Raw GCM model outputs underestimate the effects of climate warming at both hot (3-fold) and cold (8–12 fold) extremes, and overestimate (3-fold) the change under intermediate conditions. Thus, downscaling could add important insights to the standard application of coarse-scale GCMs for biophysical processes driven strongly by local microclimatic conditions.
Several studies predict rising global temperatures to increase the burden of malaria (Martens et al. 1999; Pascual et al. 2006). Others suggest no net change (Rogers and Randolph 2000), or even a decline in disease prevalence irrespective of changes in environmental conditions (Gething et al. 2010). These contrasting results reflect, in part, the complexity of the disease and the fact that parasite transmission by mosquito vectors is influenced by a range of intrinsic and extrinsic factors (Lafferty 2009). However, uncertainty also remains because analyses are often conducted across different scales, with inconsistencies in matching appropriate biological models of transmission with sufficiently resolved environmental data (Hay et al. 2006; Parham et al. 2012; Blanford et al. 2013).
Many models of malaria transmission characterize the environment using measures such as mean monthly temperature (Guerra et al. 2008; Rogers and Randolph 2000; Parham et al. 2012; Alonso et al. 2011). Yet other works have shown that essential components of mosquito and parasite biology are strongly affected by patterns of daily temperature fluctuation in addition to mean conditions (Paaijmans et al. 2009, 2010). Climate model (coupled Atmosphere–ocean General Circulation Model) simulation data are available and can be used for projecting potential climate change impacts on biophysical processes (Solomon et al. 2007; World Climate Research Programme). These General Circulation Model (GCM) data most confidently characterize climate changes at relatively coarse spatial and temporal scales (i.e. averaged over large regions and time through sub-continental monthly and seasonal averages). They are considerably less valid in characterizing local (point) projections on daily timescales. In addition, different climate models, even when constructed with the same basic large-scale physics and driven by the same climate change forcing, often give conflicting results owing, for example, to the way sub grid-scale processes such as atmospheric turbulence and cloud cover are represented (Meehl et al. 2007).
To project future climate change impacts at local levels, it is necessary to downscale coarse-scale GCM projections to higher spatial and temporal resolutions. Downscaling can potentially reduce artificial differences in responses by, in effect, using empirical relationships between scales to bypass the GCMs’ parameterizations of sub grid-scale processes (Hewitson and Crane 2006).
Here we downscale a suite of GCM simulations to derive site-specific predictions for the effects of climate warming on the potential for mosquitoes to transmit malaria in Kenya. We follow a recent study (Blanford et al. 2013) in selecting four locations that capture the broad environmental distribution of malaria, including cool upland locations (Kericho and Kitale), a warmer lower altitude site (Kisumu), and a hot savannah-like environment (Garrisa) (see Blanford et al. (2013) for full description of sites). The inclusion of Kericho is also of particular interest as this location has been at the centre of much of the malaria-climate change debate in recent years (Hay et al. 2002; Pascual et al. 2006; Chaves and Koenraadt 2010; Omumbo et al. 2011; Stern et al. 2011).
2.1 Climatic data
For each of the four locations in Kenya we developed daily downscaled temperature projections by adapting an established empirical downscaling procedure (Hewitson and Crane 2006), utilizing GCM and NCEP (National Center for Environmental Prediction) Reanalysis data, as well as meteorological station observations for daily maximum and minimum temperature at each location. The station observations come from the U.S. National Climate Data Center Global Surface Summary of the Day (GSOD) data. These are obtained through the WMO World Weather Watch program and are derived from the Integrated Surface Data, which includes observations from the USAF Climatology Center. We set a minimum of four observations a day for the data to be included, and the data set is quality controlled for random errors.1
The NCEP reanalysis data are re-gridded to a nominal 2° × 2° hexagonal grid centered on each target meteorological station, and the data from the 19 hexagonal cells centered on and surrounding the station are used to train a separate Self-Organizing Map (SOM) for each location. The SOM groups days with similar large-scale atmospheric characteristics based on the NCEP surface air temperature and specific and relative humidities at 850mb, and the sine of the Julian day. The SOM is analogous to a non-linear fuzzy clustering algorithm, where each node in the SOM represents a group of similar days. The observed temperatures at the target location (one of the four meteorological stations) are then used to construct a cumulative frequency distribution (CFD) of temperatures for each node. The days from the present (1981–2000) and future (2046–2065) GCM simulations are mapped to the SOMs and a paired maximum and minimum temperature randomly selected from the appropriate CFD. The result is an empirical transfer function that maps local temperature to the larger scale dynamical forcing in a manner that also accounts for local effects - such as topography - thus producing site-specific, diurnally-resolved climate projections. Full Methods, model validation and any associated references are available in the online version of the paper.
2.2 Malaria transmission potential
Mean temperatures were calculated as (Tmin+Tmax)/2. We used a standard method for generating realistic diurnal temperature variations (Parton and Logan 1981). Temperature was modelled at 1h intervals using the historic and the forecast minimum and maximum temperatures of each GCM (both raw and downscaled data), assuming a day length of 12h. For parameters a and n we captured the effects of temperature variation using rate summation, whereby a and n were calculated at hourly intervals, and the rates summed over a day (Paaijmans et al. 2009). For g and bc, which are described by probabilities, it is not appropriate to use rate summation so we based estimates on the mean monthly temperatures generated by the diurnal temperature models.
Although the raw GCM output and DS estimates predict similar increases in mean temperature, the actual raw GCM temperatures themselves differ markedly between models (Fig. 2, Table S3). The downscaled series show less variance (i.e. reduced uncertainty) than the raw GCM grid point series, smaller differences between GCMs, and much closer match to the empirical meteorological data (Fig. 1, and see the supporting online material). Furthermore, the nature of the differences between modeling approaches differs between sites. For Kericho, for example, the DS model estimates predict current and future mean annual temperatures of 17.5 and 19.5°C, respectively, while the raw GCM outputs predict equivalent means of 20.6 and 22.3°C. For Kisumu, on the other hand, the DS estimates predict current and future mean temperatures of 23.4 and 25.2°C, respectively, while the raw GCMs predict 20.8 and 22.5°C. Thus, raw GCM output can both under- and overestimate temperatures relative to downscaled GCM results.
With the climate data in hand we now explore the implications for malaria transmission. We focus on the influence of outdoor temperatures. This approach follows nearly all malaria-temperature research published to date. We acknowledge that adult mosquitoes can rest indoors as well as outdoors (Alonso et al. 2011; Blanford et al. 2013). However, individual mosquito species tend to exhibit different extents of endophily and there is growing evidence that current vector control tools, such as indoor residual insecticide sprays and insecticide treated nets, are selecting for outdoor biting and resting (Govella and Ferguson 2012).
Lifetime transmission potential V as estimated by the mean temperature and diurnal temperature range (DTR) given by the raw GCMs or the downscaled (DS) models (see Table S3), for recent historic (1981–2000) and future climates (2046–2065), for 4 sites across Kenya
Our results show individual GCMs to produce highly divergent estimates of mean temperatures and daily temperature range. These in turn generate a wide range of possible current and future values of mosquito lifetime transmission potential. With such variation, the raw GCM results provide only limited insight into possible effects of climate change on malaria transmission. As noted earlier, the variation among raw GCM results is due in large part to the way different models treat sub-grid-scale processes, such as convection, cloud cover and precipitation. Multiple comparison studies indicate that the multi-model (ensemble) mean is usually more valid than any individual model (Cai et al. 2009). Even so, the ensemble means of the raw GCMs provide a relatively poor description of the prevailing temperature conditions at the different sites (see Fig. 1 and online material). These findings resonate with recent studies suggesting that species distribution models based on fine-scale climate data may provide markedly different estimates of climate-change impacts than coarse-scale models (Franklin et al. 2013). GCMs utilize data averaged over grid cells ranging up to 4° latitude × 5° longitude. While GCMs are able to incorporate the effects of topographic variability on the large-scale dynamics of the atmosphere, this resolution is too coarse to resolve the topographically controlled climate variation that occurs between adjacent sites such as lowland Kisumu and highland Kericho.
The more finely tuned DS approach predicts large increases in future transmission potential in the cooler sites, Kericho and Kitale, but a reduction at the warmest site, Garissa. These results support the potential for complex ‘two-tailed’ effects of warming (Lafferty 2009), depending on the background conditions. Garissa is already at or beyond the temperature optimum for transmission (Mordecai et al. 2013), so any further increase in temperature is expected to reduce transmission potential. On the other hand, the strongly non-linear influence of temperature on transmission biology under cool conditions leads to marked increases in the V’s in the highland sites (though it should be noted that the values of lifetime transmission potential for Kericho and Kitale remain low in absolute terms). The predicted increase in transmission potential in Kisumu is less using the DS model outputs than the raw GCMs. This site is characterized by relatively consistent, year-round transmission (Blanford et al. 2013) and so even modest increases in transmission potential could translate into measurable changes in intrinsic disease risk.
As indicated previously, we use Lifetime Transmission Potential as a metric to describe relative change in the suitability of the environment for adult mosquitoes to transmit malaria. The approach follows that of others (e.g. van Lieshout et al. 2004; Weiss et al. 2014) in using a subset of all possible parameters to define relative changes in transmission suitability. Further, we consider changes in annual conditions, which overlooks potentially important effects during specific transmission seasons. Accordingly, our study is illustrative and we caution against interpreting our results as measures of changes in absolute disease risk; our basic aim is to highlight the potential for downscaling to add value to coarse scale GCM outputs (e.g. Caminade et al. 2014).
Moreover, common to nearly all climate-mosquito-malaria modeling investigations the mosquito and parasite parameter values we use to explore transmission derive largely from lab-based studies. A recent study suggested the potential for local adaptation amongst vectors and parasites creating the possibility for divergent effects of temperature due to “genotype × genotype × environment” interactions (Sternberg and Thomas 2014). However, there are few field-derived data on the temperature dependency of mosquito or parasite traits and virtually no data on malaria and mosquito local adaptation, making it difficult to explore the possible significance for transmission or control.
These caveats notwithstanding, use of downscaling techniques to identify local effects of climate warming on malaria transmission suitability could have important implications for development of local adaptation and mitigation strategies in malaria-affected areas. More generally, a growing number of studies now highlight the need to evaluate the impacts of climate change from the perspective of microclimate rather than macroclimate (De Frenne et al. 2013; Potter et al. 2013; Bakken and Angilletta 2014). Similarly, our results caution against the use of raw GCMs to explore impacts of climate change on biophysical processes that, like malaria transmission, exhibit considerable spatial heterogeneity and a dependence on high temporal variability in temperature.
This work was supported by the NSF-EID program (grant no. EF-0914384).
- Cai XM, Wang DB, Zhu TJ, Ringler C (2009) Assessing the regional variability of GCM simulations. Geo Res Letters 36. doi:10.1029/2008gl036443
- Fillinger U, Ndenga B, Githeko A, Lindsay SW (2009) Integrated malaria vector control with microbial larvicides and insecticide-treated nets in western Kenya: a controlled trial. Bull WHO 87:655–665Google Scholar
- Guerra CA, Gikandi PW, Tatem AJ, Noor AM, Smith DL, Hay SI, Snow RW (2008) The limits and intensity of Plasmodium falciparum transmission: Implications for malaria control and elimination worldwide. PLoS Med 5 (2):300–311. doi:e38Google Scholar
- Hay SI, Tatem AJ, Guerra CA, Snow RW (2006) Population at malaria risk in Africa: 2005, 2015 and 2030. Foresight studies, Department of Trade & Industry, UKGoogle Scholar
- MacDonald G (1957) The epidemiology and control of malaria. Oxford University Press, LondonGoogle Scholar
- Nakicenovic N, Alcamo J, Davis G, De Vries B, Fenhann J, Gaffin S, Gregory K, Grübler A, Jung TY, Kram T, La Rovere EL, Michaelis L, Mori S, Morita T, Pepper W, Pitcher H, Price L, Riahi K, Roehrl A, Rogner H-H, Sankovski A, Schlesinger M, Shukla P, Smith S, Swart R, Van Rooijen S, Victor N, Dadi Z (2000) Special report on emissions scenarios: a special report of working group III of the Intergovernmental panel on climate change. Cambridge, UKGoogle Scholar
- Rogers DJ, Randolph SE (2000) The global spread of malaria in a future, warmer world. Science 289 (8 September):1763–1766Google Scholar
- Solomon S, Qin D, Manning M, Alley RB, Berntsen T, Bindoff NL, Chen Z, Chidthaisong A, Gregory JM, Hegerl GC, Heimann M, Hewitson B, Hoskins BJ, Joos F, Jouzel J, Kattsov V, Lohmann U, Matsuno T, Molina M, Nicholls N, Overpeck J, Raga G, Ramaswamy V, Ren J, Rusticucci M, Somerville R, Stocker TF, Whetton P, Wood RA, Wratt D (2007) Contribution of working group I to the fourth assessment report of the intergovernmental panel on climate change. Climate change 2007: the physical science basis. Cambridge, UKGoogle Scholar
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