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Czechoslovak Journal of Physics

, Volume 49, Supplement 1, pp 817–822 | Cite as

Production of AC-225 and application of the BI-213 daughter in cancer therapy

  • L. Koch
  • C. Apostolidis
  • W. Janssens
  • R. Molinet
  • J. Van Geel
Production and Application of Radionuclides

Abstract

There are several ongoing medical trials to use Bi-213 conjugated to monoclonal antibodies to kill tumour-cells of various cancer types. The institute is supplying Ac-225 generators for the test and is itself engaged in in-vitro cytotoxicity tests. Nuclear reactions leading to Ac-225 are discussed. The present supply of Ac-225 stems from Th-229 decay obtained from aged U-233. From the possible alternative the reactions Ra-226 (p, 2n) Ac-225 is presently favoured. The fabrication of a Ac-225 for Bi-213 generator will be described.

Keywords

Production Mode Linear Energy Transfer Titaniumphosphate High Flux Reactor Present Supply 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Institute of Physics, Acad. Sci. CR 1999

Authors and Affiliations

  • L. Koch
    • 1
  • C. Apostolidis
    • 1
  • W. Janssens
    • 1
  • R. Molinet
    • 1
  • J. Van Geel
    • 1
  1. 1.Institute for Transuranium ElementsEuropean Commission-JRCKarlsruheGermany

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