Child Psychiatry & Human Development

, Volume 41, Issue 6, pp 641–648 | Cite as

Buspirone Versus Methylphenidate in the Treatment of Attention Deficit Hyperactivity Disorder: A Double-Blind and Randomized Trial

  • Rozita Davari-Ashtiani
  • Mahin Eslami Shahrbabaki
  • Katayoon Razjouyan
  • Homayoun Amini
  • Homa Mazhabdar
Original Article


The efficacy and side effects of buspirone compared with methylphenidate (MPH) in the treatment of children with attention-deficit/hyperactivity disorder (ADHD). A total of 34 children with ADHD as defined by DSM-IV-TR were randomized to buspirone or methylphenidate dosed on weight-adjusted basis at buspirone (0.5 mg/kg/day) and methylphenidate (0.3–1 mg/kg/day) for a 6-week double-blind clinical trial. The principle measures of outcome were the teacher and parent ADHD Rating Scale. The side effects were assessed by the special side effect checklist of each drug. In both groups, the scores of teacher and parent ADHD Rating Scale significantly declined on the 6th week as compared to baseline (p = 0.001). These effects were observed in the subscales too. No significant differences were observed between the two protocols on the total scores of parent and teacher ADHD Rating Scale, but methylphenidate was superior to buspirone in decreasing the symptoms of inattention. The side effects of buspirone were mild and rare in comparison with MPH. Buspirone has a favorable side-effects profile. It also has clinically and statistically significant impacts on improving the ADHD symptoms in children. These preliminary findings of the efficacy of buspirone in children with ADHD need large and cross-over studies.


ADHD Buspirone Methylphenidate 



Attention deficit hyperactivity disorder





This work was supported in part by the grant from the Behavioral Sciences Research Center of Shahid Beheshti University of Medical Sciences (Tehran, Iran). The authors express their gratitude to Ali Fakhrabadi and Ebrahim Parvin for editing the manuscript.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Rozita Davari-Ashtiani
    • 1
    • 2
  • Mahin Eslami Shahrbabaki
    • 1
  • Katayoon Razjouyan
    • 1
  • Homayoun Amini
    • 3
    • 4
  • Homa Mazhabdar
    • 1
  1. 1.Imam Hossein Hospital, Department of PsychiatryShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Behavioral Sciences Research CenterShahid Beheshti University of Medical SciencesTehranIran
  3. 3.Psychiatry and Psychology Research CenterTehran University of Medical SciencesTehranIran
  4. 4.Roozbeh Hospital, Department of PsychiatryTehran University of Medical SciencesTehranIran

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