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Child Psychiatry and Human Development

, Volume 37, Issue 3, pp 241–253 | Cite as

Fluoxetine Monotherapy in Attention-Deficit/Hyperactivity Disorder and Comorbid Non-Bipolar Mood Disorders in Children and Adolescents

  • Humberto Quintana
  • Grant J. Butterbaugh
  • William Purnell
  • Ann K. Layman
Original Paper

Abstract

Children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for developing comorbid non-bipolar mood disorders. Fluoxetine monotherapy is an established treatment for pediatric mood disorders; however its efficacy in ADHD and comorbid mood disorder is unknown. Therefore, we evaluated 30 children who met DSM-IV criteria for ADHD and comorbid non-bipolar mood disorders in a prospective, 6–12-week open-label, study of fluoxetine monotherapy. Fluoxetine was associated with significant decreases in the severity of depressive symptoms, and also, associated with significant decreases on subscales of inattention/overactivity and aggression/defiant symptoms—47% of participants were much or very much improved without observed adverse effects.

Keywords

Fluoxetine Attention-deficit/hyperactivity disorder Mood disorders Children Adolescents 

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Notes

Acnowledgments

The authors are thankful to Eli Lilly for their support of this research through Grant ID # B1Y-MC-X143. We also want to thank the LSUHSC IRB that approved this study and that has encouraged our research in child and adolescent psychiatry.

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Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Humberto Quintana
    • 1
  • Grant J. Butterbaugh
    • 1
  • William Purnell
    • 1
  • Ann K. Layman
    • 1
  1. 1.Department of PsychiatryLouisiana State University Health Sciences Center School of Medicine at New OrleansNew OrleansUSA

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