Fluoxetine Monotherapy in Attention-Deficit/Hyperactivity Disorder and Comorbid Non-Bipolar Mood Disorders in Children and Adolescents
Children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for developing comorbid non-bipolar mood disorders. Fluoxetine monotherapy is an established treatment for pediatric mood disorders; however its efficacy in ADHD and comorbid mood disorder is unknown. Therefore, we evaluated 30 children who met DSM-IV criteria for ADHD and comorbid non-bipolar mood disorders in a prospective, 6–12-week open-label, study of fluoxetine monotherapy. Fluoxetine was associated with significant decreases in the severity of depressive symptoms, and also, associated with significant decreases on subscales of inattention/overactivity and aggression/defiant symptoms—47% of participants were much or very much improved without observed adverse effects.
KeywordsFluoxetine Attention-deficit/hyperactivity disorder Mood disorders Children Adolescents
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The authors are thankful to Eli Lilly for their support of this research through Grant ID # B1Y-MC-X143. We also want to thank the LSUHSC IRB that approved this study and that has encouraged our research in child and adolescent psychiatry.
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