Transposable elements and the multidimensional genome
There is no such thing as “junk DNA.” Indeed, a suite of discoveries made over the past few decades have put to rest this misnomer and have identified many important roles that so-called junk DNA provides to both genome structure and function (this special issue; Biémont and Vieira 2006; Jeck et al. 2013; Elbarbary et al. 2016; Akera et al. 2017; Chen and Yang 2017; Chuong et al. 2017). Nevertheless, given the historical focus on coding regions of the genome, our understanding of the biological function of non-coding regions (e.g., repetitive DNA, transposable elements) remains somewhat limited, and therefore, all those enigmatic and poorly studied regions of the genome that were once identified as junk are instead best viewed as genomic “dark matter.” This special issue of Chromosome Researchdelves into the exciting world of genomic dark matter by focusing on the contribution that transposable elements have made to genome innovation and function. Collectively, these papers address a...
Keywordsepigenetics genomics gene regulation genome innovation mobile elements sporadic disease RNA biology
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