It is now widely recognized that the packaging of genomic DNA together with core histones, linker histones, and other functional proteins into chromatin profoundly influences nuclear processes such as transcription, replication, repair and recombination. How chromatin structure modulates the expression and maintenance of knowledge encoded in eukaryotic genomes, and how these processes take place within the context of a highly complex and compacted genomic chromatin environment remains a major unresolved question in biology. Here we review recent advances in our understanding of how nucleosome and chromatin structure may have to adapt to promote these vital functions.
Key wordschromatin remodelling histone histone chaperone nucleosome
Unable to display preview. Download preview PDF.
- Chakravarthy S, Bao Y, Roberts VA, Tremethick DJ, Luger K (2004) Structural characterisation of histone H2A variants. Cold Spring Harb Symp Quant Biol 69: 227–234.Google Scholar
- Hill DA, Peterson CL, Imbalzano AN (2005) Effects of HMGN1 on chromatin structure and SWI/SNF-mediated chromatin remodeling. J Biol Chem 280: 41777–41783.Google Scholar
- Luger K, Richmond TJ (1998a) DNA binding within the nucleosome core. Curr Opin Struck Biol 8: 33–40.Google Scholar
- McBryant SJ, Adams VH, Hansen JC (2006) Chromatin architectural proteins. Chromosome Res 14: 39–51.Google Scholar
- Spangenberg C, Eisfeld, K Stunkel W et al. (1998) The mouse mammary tumour virus promoter positioned on a tetramer of histones H3 and H4 binds nuclear factor 1 and OTF1. J Mol Biol 275: 725–739.Google Scholar