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Chromosome Research

, Volume 14, Issue 1, pp 27–37 | Cite as

Base excision repair in nucleosome substrates

  • Indu Jagannathan
  • Hope A. Cole
  • Jeffrey J. Hayes
Article

Abstract

Eukaryotic cells must repair DNA lesions within the context of chromatin. Much of our current understanding regarding the activity of enzymes involved in DNA repair processes comes from in-vitro studies utilizing naked DNA as a substrate. Here we review current literature investigating how enzymes involved in base excision repair (BER) contend with nucleosome substrates, and discuss the possibility that some of the activities involved in BER are compatible with the organization of DNA within nucleosomes. In addition, we examine evidence for the role of accessory factors, such as histone modification enzymes, and the role of the histone tail domains in moderating the activities of BER factors on nucleosomal substrates.

Key words

base excision repair chromatin nucleosome 

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Copyright information

© Springer 2006

Authors and Affiliations

  • Indu Jagannathan
    • 1
  • Hope A. Cole
    • 1
  • Jeffrey J. Hayes
    • 1
  1. 1.Department of Biochemistry and BiophysicsUniversity of Rochester Medical CenterRochesterUSA

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