Drosophila telomeres: the non-telomerase alternative
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In most eukaryotes, telomeres are composed of simple repetitive sequences renewable by telomerase. By contrast, Drosophila telomeres comprise arrays of non-LTR retrotransposons HeT-A, TART, and TAHRE belonging to three different families. However, closer inspection reveals that the two quite different telomere systems share quite a few components and regulatory circuits. Here we present the current knowledge on Drosophila telomeres and discuss the possible mechanisms of telomere length control.
Key wordsDrosophila retrotransposons TAS telomere t-loop
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- Abad JP, de Pablos B, Osoegawa K, de Jong PJ, Martin-Gallardo A, Villasante A (2004a) Genomic analysis of Drosophila melanogaster telomeres: full-length copies of HeT-A and TART elements at the telomeres. Mol Biol Evol 21: 1613–1619.Google Scholar
- Belenkaya T, Soldatov A, Nabirochkina E, Birjukova I, Georgieva S, Georgiev P (1998) The allele of the polyhomeotic gene induced by P element insertion encodes a new chimeric protein, that negatively regulates the expression of P-induced alleles in the yellow locus of Drosophila melanogaster. Genetics 150: 687–697.PubMedGoogle Scholar
- Cenci G, Siriaco G, Raffa GD, Kellum R, Gatti M (2003) The Drosophila HOAP protein is required for telomere capping. Nat Cell Biol 5: 82–84.Google Scholar
- Melnikova L, Biessmann H, Georgiev P (2005) The Ku protein complex is involved in length regulation of Drosophila telomeres. Genetics 170: 221–235.Google Scholar
- Rashkova S, Karam SE, Kellum R, Pardue M-L (2002a) Gag proteins of the two Drosophila telomeric retrotransposons are targeted to chromosome ends. J Cell Sci 159: 397–402.Google Scholar
- Vagin VV, Klenov MS, Kalmykova AI, Stolyarenko AD, Kotelnikov RN, Gvozdev VA (2004) The RNA interference proteins and vasa locus are involved in the silencing of retrotransposons in the female germline of Drosophila melanogaster. RNA Biol 1: 54–58.Google Scholar