Putative Trace-Amine Associated Receptor 5 (TAAR5) Agonist α-NETA Increases Electrocorticogram Gamma-Rhythm in Freely Moving Rats
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Cortical gamma rhythm is involved in transmission of information (communication) between brain areas that are believed to be involved in the pathogenesis of cognitive dysfunctions. Trace amines represent a group of endogenous biogenic amines that are known to be involved in modulation of function of classical monoamines, such as dopamine. To evaluate potential modulatory influence of a specific receptor for trace amines Trace Amine-Associated Receptor 5 (TAAR5) on the dopamine system, we used HPLC measurements of dopamine and its metabolites in the mouse striatum following administration of the putative TAAR5 agonist α-NETA. Administration of α-NETA caused significant modulation of dopaminergic system as evidenced by an altered dopamine turnover rate in the striatum. Then, to evaluate potential modulatory influence of TAAR5 on the rat brain gamma rhythm, we investigated the changes of electrocorticogram (ECoG) spectral power in the gamma-frequency range (40–50 Hz) following administration of the putative TAAR5 agonist α-NETA. In addition, we analyzed the changes of spatial synchronization of gamma oscillations of rat ECoG by multichannel recording. Significant complex changes were observed in the ECoG spectrum, including an increase in the spectral power in the ranges of delta (1 Hz), theta (7 Hz), and gamma rhythms (40–50 Hz) after the introduction of α-NETA. Furthermore, a decrease in the spatial synchronization of gamma oscillations of 40-50 Hz and its increase for theta oscillations of 7 Hz were detected after the introduction of α-NETA. In conclusion, putative TAAR5 agonist α-NETA can modulate striatal dopamine transmission and cause significant alterations of gamma rhythm of brain activity in a manner consistent with schizophrenia-related deficits described in humans and experimental animals. These observations suggest a role of TAAR5 in the modulation of cognitive functions affected in brain pathologies.
KeywordsTrace amines Dopamine α-NETA TAAR5 Gamma rhythm Theta-rhythm
This study was funded by the Russian Science Foundation grant N 19-75-30008
Compliance with Ethical Standards
Conflict of interest
All authors declare that they have no conflict of interest.
All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.
- Hebb DO (1949) The organization of behavior. Wiley, New YorkGoogle Scholar
- Kanunikov IE, Lamkin PE, Belov DR (1999) Indicators of EEG spatial synchronization in schoolchildren 10–12 years old in normal and with learning difficulties. Russ J Physiol 85(3):360–371 (In Russ) Google Scholar
- Klimash AV, Tsitseroshin MN, Shepovalnikov AN, Zajceva LG, Kondakov EN, Borovikova VN (2010) Disorders of the spatiotemporal organization of the brain’s bioelectrical activity in patients with different depressions of consciousness after severe head injury. Human Physiol 36(5):535–549CrossRefGoogle Scholar
- Livanov MN (1973) Prostranstvennaya sinhronizaciya biopotencialov golovnogo mozga [Spatial synchronization of brain biopotentials]. Nauka, MoscowGoogle Scholar
- Livanov MN, Sviderskaya NE (1984) Psychological aspects of the phenomenon of potentials spatial synchronization. Psychol J 5(5):71–83 (In Russ) Google Scholar
- Shepovalnikov AN, Tsitseroshin MN, Zaitseva LG, Galperina EI (2012) Features of systemic interaction of different cortex areas of the left and right brain hemispheres in different sleep stages in humans. Russ J Physiol 98(10):1228–1241 (In Russ) Google Scholar
- Sviderskaya NE (1987) Sinhronnaya aktivnost mozga i psihisheskie processi [Synchronous electrical activity of the brain and mental processes]. Nauka, MoscowGoogle Scholar
- Weinberger DR, Harrison PJ (2011) Schizophrenia. Wiley-BlackwellGoogle Scholar