Cellular and Molecular Neurobiology

, Volume 39, Issue 1, pp 11–29 | Cite as

Hypothalamic Inflammation at a Crossroad of Somatic Diseases

  • Boris MravecEmail author
  • Lubica Horvathova
  • Alena Cernackova
Review Paper


Various hypothalamic nuclei function as central parts of regulators that maintain homeostasis of the organism. Recently, findings have shown that inflammation in the hypothalamus may significantly affect activity of these homeostats and consequently participate in the development of various somatic diseases such as obesity, diabetes, hypertension, and cachexia. In addition, hypothalamic inflammation may also affect aging and lifespan. Identification of the causes and mechanisms involved in the development of hypothalamic inflammation creates not only a basis for better understanding of the etiopathogenesis of somatic diseases, but for the development of new therapeutic approaches for their treatment, as well.


Aging Cachexia Cytokines Diabetes mellitus Hypertension Hypothalamus Inflammation Obesity 



This work was supported by the Slovak Research and Development Agency (APVV-17-0090), VEGA Grant 2/0028/16, and EU Grant from cross-border cooperation program Interreg V-A SK-AT V014 - NutriAging. We wish to thank Dr. Ken Goldstein of ScienceDocs ( for the editing of this paper.

Author Contributions

All authors contributed to the preparation of manuscript, BM finalized manuscript and prepared figures.

Compliance with Ethical Standards

Conflict of interest

We declare that we have no conflict of interest.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute of Physiology, Faculty of MedicineComenius University in BratislavaBratislavaSlovakia
  2. 2.Biomedical Research Center, Institute of Experimental EndocrinologySlovak Academy of SciencesBratislavaSlovakia

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