Cellular and Molecular Neurobiology

, Volume 37, Issue 3, pp 499–509 | Cite as

Caffeoylquinic Acid Derivatives Protect SH-SY5Y Neuroblastoma Cells from Hydrogen Peroxide-Induced Injury Through Modulating Oxidative Status

  • Xiao-Wen Jiang
  • Jun-Peng Bai
  • Qiao Zhang
  • Xiao-Long Hu
  • Xing Tian
  • Jun Zhu
  • Jia Liu
  • Wei-Hong Meng
  • Qing-Chun Zhao
Original Research
First Online:
Received:
Accepted:

Abstract

Oxidative stress has been confirmed as a contribution to the pathogenesis and pathophysiology of many neurological disorders such as Alzheimer’s disease and Parkinson’s disease. Caffeoylquinic acids (CQAs) are considered to have anti-oxidative stress ability in a previous study, but the structure–activity relationships (SARs) of CQAs in neuroprotective effects are still unclear. In the present study, we primarily expound the SARs of CQAs in counteracting H2O2-induced injury in SH-SY5Y cells. We found that CQAs (1–10) represented the protection of SH-SY5Y cells against H2O2-induced injury in varying degrees and malonyl groups could obviously increase the anti-oxidative stress ability of CQAs. Intensive studies of 4,5-O-dicaffeoyl-1-O-(malic acid methyl ester)-quinic acid (MDCQA) indicated that the mechanisms could potentially involve activation of endogenous antioxidant enzymes and the regulation of the phosphorylation of MAPKs and AKT. In conclusion, MDCQA could serve as a neuroprotective agent with a potential to attenuate oxidative stress.

Keywords

MDCQA Caffeoylquinic acid Neuroprotection ROS SH-SY5Y 
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Notes

Acknowledgments

This work was supported by the National Science and Technology Major Project, People’s Republic of China (Project No. 2014ZX09J14101-05C).

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Xiao-Wen Jiang
    • 1
    • 2
  • Jun-Peng Bai
    • 2
  • Qiao Zhang
    • 2
  • Xiao-Long Hu
    • 2
  • Xing Tian
    • 2
  • Jun Zhu
    • 2
  • Jia Liu
    • 2
  • Wei-Hong Meng
    • 1
  • Qing-Chun Zhao
    • 1
  1. 1.Department of PharmacyGeneral Hospital of Shenyang Military Area CommandShenyangChina
  2. 2.Department of Traditional Chinese MedicineShenyang Pharmaceutical UniversityShenyangChina

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