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Cellular and Molecular Neurobiology

, Volume 25, Issue 3–4, pp 475–483 | Cite as

Alzheimer’s Disease—A Dysfunction in Cholesterol and Lipid Metabolism

  • Walter J. LukiwEmail author
  • Miguel Pappolla
  • Ricardo Palacios Pelaez
  • Nicolas G. Bazan
Article

Abstract

1. Strong etiological association exists between dysfunctional metabolism of brain lipids, age-related changes in the cerebral vasculature and neurodegenerative features characteristic of Alzheimer’s disease (AD) brain.

2. In this short review, recent experimental evidence for these associations is further discussed below.

Key Words

Alzheimer amyloid cholesterol lipids oxidation statins 

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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Walter J. Lukiw
    • 1
    • 2
    Email author
  • Miguel Pappolla
    • 1
    • 3
  • Ricardo Palacios Pelaez
    • 4
  • Nicolas G. Bazan
    • 1
    • 2
  1. 1.LSU Neuroscience CenterLouisiana State University Health Sciences CenterNew Orleans
  2. 2.Department of OpthalmologyLouisiana State University Health Sciences CenterNew Orleans
  3. 3.Department of NeurologyLouisiana State University Health Sciences CenterNew Orleans
  4. 4.Diater PharmaceuticalsSpain

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