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Cellulose

, Volume 26, Issue 2, pp 1221–1230 | Cite as

Physical nanochitin/microemulsion composite hydrogels for hydrophobic Nile Red release under in vitro physiological conditions

  • Zhiguo Wang
  • Rong Wang
  • Pengbo Xu
  • Juan Yu
  • Liang Liu
  • Yimin FanEmail author
Original Paper
  • 116 Downloads

Abstract

A physical composite nanochitin/microemulsion (NCh/ME) hydrogel for a prolonged release of hydrophobic compounds (drugs) under in vitro physiological conditions was investigated. A strong physical hydrogel was prepared by an alkali gas phase coagulation bath composting NCh with an oil in water ME in which a hydrophobic dye, Nile Red (NR), was embedded to simulate a drug release process. Different release conditions, such as concentration of NCh, diameter of ME, temperature and specific surface areas, were studied. The results showed that the NCh/ME composite hydrogel effectively encapsulated NR with a prolonged release period of 60 h in phosphate-buffered saline (PBS pH 7.4, similar to physiological conditions), which demonstrated the significance of NCh/ME composite hydrogels for hydrophobic compound (drug) delivery.

Graphical abstract

Keywords

Nanochitin Hydrogel Microemulsion Drug release 

Notes

Acknowledgments

We are grateful for financial support from the National Key R&D Program of China (2016YFD0600803) and the Postgraduate Research and Practice Innovation Program of Jiangsu Province (KYCX17-0852).

References

  1. Arora S, Ali J, Ahuja A et al (2005) Floating drug delivery systems: a review. AAPS PharmSciTech 6(3):E372–E390CrossRefGoogle Scholar
  2. Bhattarai N, Gunn J, Zhang M (2010) Chitosan-based hydrogels for controlled, localized drug delivery. Adv Drug Deliv Rev 62(1):83–99CrossRefGoogle Scholar
  3. Chang C, Chen S, Zhang L (2011) Novel hydrogels prepared via direct dissolution of chitin at low temperature: structure and biocompatibility. J Mater Chem 21(11):3865–3871CrossRefGoogle Scholar
  4. Chen C, Yano H, Li D et al (2015) Preparation of high-strength α-chitin nanofiber-based hydrogels under mild conditions. Cellulose 22(4):2543–2550CrossRefGoogle Scholar
  5. Delmar K, Bianco-Peled H (2016) Composite chitosan hydrogels for extended release of hydrophobic drugs. Carbohydr Polym 136:570–580CrossRefGoogle Scholar
  6. Fan Y, Saito T, Isogai A (2010) Individual chitin nano-whiskers prepared from partially deacetylated α-chitin by fibril surface cationization. Carbohydr Polym 79(4):1046–1051CrossRefGoogle Scholar
  7. Focher B, Naggi A, Torri G et al (1992) Structural differences between chitin polymorphs and their precipitates from solutions-evidence from CP-MAS 13C-NMR, FT-IR and FT-Raman spectroscopy. Carbohydr Polym 17(2):97–102CrossRefGoogle Scholar
  8. Guillot F, Domard A (2005) Composition for cutaneous repair and cicatrization comprising exclusively a true physical hydrogel of chitosan. U.S. patent application 10/915, 621.2-24Google Scholar
  9. Hu X, Tang Y, Wang Q et al (2011) Rheological behaviour of chitin in NaOH/urea aqueous solution. Carbohydr Polym 83(3):1128–1133CrossRefGoogle Scholar
  10. Jayakumar R, Menon D, Manzoor K et al (2010) Biomedical applications of chitin and chitosan based nanomaterials—a short review. Carbohydr Polym 82(2):227–232CrossRefGoogle Scholar
  11. Josef E, Barat K, Barsht I et al (2013) Composite hydrogels as a vehicle for releasing drugs with a wide range of hydrophobicities. Acta Biomater 9(11):8815–8822CrossRefGoogle Scholar
  12. Khurma JR, Nand AV (2008) Temperature and pH sensitive hydrogels composed of chitosan and poly(ethylene glycol). Polym Bull 59(6):805–812CrossRefGoogle Scholar
  13. Klossner RR, Queen HA, Coughlin AJ et al (2008) Correlation of chitosan’s rheological properties and its ability to electrospin. Biomacromolecules 9(10):2947–2953CrossRefGoogle Scholar
  14. Kogan A, Garti N (2006) Microemulsions as transdermal drug delivery vehicles. Adv Colloid Interface Sci 123:369–385CrossRefGoogle Scholar
  15. Lawrence MJ, Rees GD (2000) Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev 45(1):89–121CrossRefGoogle Scholar
  16. Li L, Lin Z, Yang X et al (2009) A novel cellulose hydrogel prepared from its ionic liquid solution. Chin Sci Bull 54(9):1622–1625Google Scholar
  17. Liu J, Zhang L, Yang Z et al (2011) Controlled release of paclitaxel from a self-assembling peptide hydrogel formed in situ and antitumor study in vitro. Int J Nanomed 6:2143CrossRefGoogle Scholar
  18. Liu L, Lv H, Jiang J et al (2015a) Reinforced chitosan beads by chitin nanofibers for the immobilization of β-glucosidase. RSC Adv 5(113):93331–93336CrossRefGoogle Scholar
  19. Liu Y, Gu J, Zhang J et al (2015b) LiFePO4 nanoparticles growth with preferential (010) face modulated by Tween-80. RSC Adv 5(13):9745–9751CrossRefGoogle Scholar
  20. Liu L, Wang R, Yu J et al (2016) Robust self-standing chitin nanofiber/nanowhisker hydrogels with designed surface charges and ultralow mass content via gas phase coagulation. Biomacromolecules 17(11):3773–3781CrossRefGoogle Scholar
  21. Mir VG, Heinämäki J, Antikainen O et al (2008) Direct compression properties of chitin and chitosan. Eur J Pharm Biopharm 69(3):964–968CrossRefGoogle Scholar
  22. Pillai CKS, Paul W, Sharma CP (2009) Chitin and chitosan polymers: chemistry, solubility and fiber formation. Prog Polym Sci 34(7):641–678CrossRefGoogle Scholar
  23. Rwei SP, Lyu MS, Wu P et al (2009) Sol/gel transition and liquid crystal transition of HPC in ionic liquid. Cellulose 16(1):9–17CrossRefGoogle Scholar
  24. Sriupayo J, Supaphol P, Blackwell J et al (2005) Preparation and characterization of α-chitin whisker-reinforced chitosan nanocomposite films with or without heat treatment. Carbohydr Polym 62(2):130–136CrossRefGoogle Scholar
  25. Tenjarla S (1999) Microemulsions: an overview and pharmaceutical applications. Crit Rev Ther Drug Carrier Syst 16(5):461–521CrossRefGoogle Scholar
  26. Wang R, Liu L, Yu J et al (2017) Versatile protonic acid mediated preparation of partially deacetylated chitin nanofibers/nanowhiskers and their assembling of nano-structured hydro- and aero-gels. Cellulose 12:1–12Google Scholar

Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Light Industry and Food Engineering, College of Chemical EngineeringNanjing Forestry UniversityNanjingChina
  2. 2.Jiangsu Key Lab of Biomass-Based Green Fuel and Chemicals, College of Chemical EngineeringNanjing Forestry UniversityNanjingChina

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