Physical nanochitin/microemulsion composite hydrogels for hydrophobic Nile Red release under in vitro physiological conditions
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A physical composite nanochitin/microemulsion (NCh/ME) hydrogel for a prolonged release of hydrophobic compounds (drugs) under in vitro physiological conditions was investigated. A strong physical hydrogel was prepared by an alkali gas phase coagulation bath composting NCh with an oil in water ME in which a hydrophobic dye, Nile Red (NR), was embedded to simulate a drug release process. Different release conditions, such as concentration of NCh, diameter of ME, temperature and specific surface areas, were studied. The results showed that the NCh/ME composite hydrogel effectively encapsulated NR with a prolonged release period of 60 h in phosphate-buffered saline (PBS pH 7.4, similar to physiological conditions), which demonstrated the significance of NCh/ME composite hydrogels for hydrophobic compound (drug) delivery.
KeywordsNanochitin Hydrogel Microemulsion Drug release
We are grateful for financial support from the National Key R&D Program of China (2016YFD0600803) and the Postgraduate Research and Practice Innovation Program of Jiangsu Province (KYCX17-0852).
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