Advertisement

Cellulose

pp 1–11 | Cite as

Development of bilayer films based on shellac and esterified cellulose nanocrystals for buccal drug delivery

  • Lirong Tang
  • Biyun Hong
  • Tao Li
  • Biao Huang
Original Paper
  • 5 Downloads

Abstract

Bilayer films were fabricated based on natural-based and biocompatible polymers such as esterified cellulose nanocrystals (ECNCs) and shellac, aiming for use in buccal drug delivery. Baicalin was used as the model drug. The swelling properties, drug loading and mechanical properties of films were evaluated and further characterized for mucoadhesion and in vitro drug release properties. The film (F2) containing ECNCs 45%, shellac 25% and polyethylene glycol 30% shows the best properties for the development of the film formulation. The swelling capacity of films was in the range of 36.5 ± 4.1–279.2 ± 14.1%. In vitro drug release shows that anomalous transport behavior indicates that transport includes drug diffusion and polymer relaxation. For film F2, the tensile strength and adhesion strength reaches to the maximum value of 21.57 ± 0.83 MPa and 0.073 ± 0.004 N, respectively. The interfacial interactions between drug and film components were confirmed by FTIR and XRD.

Keywords

Bilayer films Shellac Esterified cellulose nanocrystals Carriers Buccal drug delivery 

Notes

Acknowledgments

We appreciate the generous financial support of Special Scientific Research Fund for Public Service Sectors of Forestry (Grant No. 201504603), the Natural Science Foundation of Fujian Province of China (Grant No. 2016J01088), Chemicals and Science Foundation for Distinguished Young Scholars of Fujian Agricultural and Forestry University (Grant No. xjq201422) and Plan for the training of Outstanding Young Scientific Research Personnel in higher education institutions of Fujian Province (selected in 2017).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. Ansari M, Sadarani B, Majumdar A (2018) Optimization and evaluation of mucoadhesive buccal films loaded with resveratrol. J Drug Deliv Sci Technol 44:278–288CrossRefGoogle Scholar
  2. Arca HC, Mosquera-Giraldo LI, Bi V, Xu D, Taylor LS, Edgar KJ (2018) Pharmaceutical applications of cellulose ethers and cellulose ether esters. Biomacromolecules 19(7):2351–2376CrossRefGoogle Scholar
  3. Berlioz S, Molina-Boisseau S, Nishiyama Y, Heux L (2009) Gas-phase surface esterification of cellulose microfibrils and whiskers. Biomacromolecules 10(8):2144–2151CrossRefGoogle Scholar
  4. Boateng JS, Popescu AM (2016) Composite bi-layered erodible films for potential ocular drug delivery. Colloids Surf B 145:353–361CrossRefGoogle Scholar
  5. Chang HH, Yi PL, Cheng CH, Lu CY, Hsiao YT, Tsai YL, Li CL, Chang FC (2011) Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. J Ethnopharmacol 135(2):359–368CrossRefGoogle Scholar
  6. Corrigan DO, Healy AM, Corrigan OI (2002) The effect of spray drying solutions of polyethylene glycol (PEG) and lactose/PEG on their physicochemical properties. Int J Pharm 235:193–205CrossRefGoogle Scholar
  7. Cui F, He C, Yin L, Qian F, He M, Tang C, Yin C (2007) Nanoparticles incorporated in bilaminated films: a smart drug delivery system for oral formulations. Biomacromolecules 8:2845–2850CrossRefGoogle Scholar
  8. de Souza DF, Goebel K, Andreazza IF (2013) Development of enteric coated sustained release minitablets containing mesalamine. Braz J Pharm Sci 49(3):529–536CrossRefGoogle Scholar
  9. Desai KGH (2017) Polymeric drug delivery systems for intraoral site-specific chemoprevention of oral cancer. J Biomed Mater Res Part B Appl Biomater 106(3):1383–1413CrossRefGoogle Scholar
  10. Dong S, Cho HJ, Lee YW, Roman M (2014) Synthesis and cellular uptake of folic acid-conjugated cellulose nanocrystals for cancer targeting. Biomacromolecules 15(5):1560–1567CrossRefGoogle Scholar
  11. Duan C, Matsumura S, Kariya N, Nishimura M, Shimono T (2007) In vitro antibacterial activities of Scutellaria baicalensis Georgi against cariogenic bacterial. Pediatr Dent J 17(1):58–64CrossRefGoogle Scholar
  12. Edgar KJ (2007) Cellulose esters in drug delivery. Cellulose 14:49–64CrossRefGoogle Scholar
  13. French AD (2014) Idealized powder diffraction patterns for cellulose polymorphs. Cellulose 21:885–896CrossRefGoogle Scholar
  14. Guo R, Lan Y, Xue W, Cheng B, Zhang Y, Wang C, Ramakrishna S (2017) Collagen-cellulose nanocrystal scaffolds containing curcumin-loaded microspheres on infected full-thickness burns repair. J Tissue Eng Regener Med 11(12):3544–3555CrossRefGoogle Scholar
  15. Jain SK, Jain A, Gupta Y, Kharya A (2008) Design and development of a mucoadhesive buccal film bearing progesterone. Pharmazie 63:129–135PubMedGoogle Scholar
  16. Jang E, Cha S, Choi S, Cha J (2014) Combination effects of baicalein with antibiotics against oral pathogens. Arch Oral Biol 59(1):1233–1241CrossRefGoogle Scholar
  17. Jorfi M, Foster EJ (2015) Recent advances in nanocellulose for biomedical applications. J Appl Polym Sci 132:41719CrossRefGoogle Scholar
  18. Justin R, Chen B (2014) Characterisation and drug release performance of biodegradable chitosan-graphene oxide nanocomposites. Carbohydr Polym 103:70–80CrossRefGoogle Scholar
  19. Leung KC, Seneviratne CJ, Li X, Leung PC, Lau CBS, Wong C, Pang KY, Wong CW, Wat E, Jin L (2016) Synergistic antibacterial effects of nanoparticles encapsulated with Scutellaria baicalensis and pure chlorhexidine on oral bacterial biofilms. Nanomaterials 6:61CrossRefGoogle Scholar
  20. Luo K, Yin J, Khutoryanskaya OV, Khutoryanskiy VV (2008) Mucoadhesive and elastic films based on blends of chitosan and hydroxyethylcellulose. Macromol Biosci 8:184–192CrossRefGoogle Scholar
  21. Ma K, Qiu Y, Fu Y, Ni Q (2017) Improved shellac mediated nanoscale application drug release effect in a gastric-site drug delivery system. RSC Adv 7:53401–53406CrossRefGoogle Scholar
  22. Meneguin AB, Cury BSF, dos Santos AM, Franco DF, Barud HS, da Silva Filho EC (2017) Resistant starch/pectin free-standing films reinforced with nanocellulose intended for colonic methotrexate release. Carbohydr Polym 157:1013–1023CrossRefGoogle Scholar
  23. Messaoud GB, Sánchez-González L, Probst L, Jeandel C, Arab-Tehrany E, Desobry S (2016) Physico-chemical properties of alginate/shellac aqueous-core capsules: influence of membrane architecture on riboflavin release. Carbohydr Polym 144(25):428–437CrossRefGoogle Scholar
  24. Mo Y, Guo R, Zhang Y, Xue W, Cheng B, Zhang Y (2017) Controlled dual delivery of angiogenin and curcumin by electrospun nanofibers for skin regeneration. Tissue Eng Part A 23(13–14):597–608CrossRefGoogle Scholar
  25. Montenegro-Nicolini M, Morales JO (2017) Overview and future potential of buccal mucoadhesive films as drug delivery systems for biologics. AAPS PharmSciTech 18(1):3–14CrossRefGoogle Scholar
  26. Nurani M, Akbari V, Taheri A (2017) Preparation and characterization of metformin surface modified cellulose nanofiber gel and evaluation of its anti-metastatic potentials. Carbohydr Polym 165:322–333CrossRefGoogle Scholar
  27. Oprea A, Profire L, Lupusoru CE, Ghiciuc CM, Ciolacu D, Vasile C (2012) Synthesis and characterization of some cellulose/chondroitin sulphate hydrogels and their evaluation as carriers for drug delivery. Carbohydr Polym 87:721–729CrossRefGoogle Scholar
  28. Peppas NA, Huang Y (2004) Nanoscale technology of mucoadhesive interactions. Adv Drug Deliv Rev 56(11):1675–1687CrossRefGoogle Scholar
  29. Phan The D, Debeaufort F, Luu D, Voilley A (2008) Moisture barrier, wetting and mechanical properties of shellac/agar or shellac/cassava starch bilayer bio-membrane for food applications. J Membr Sci 325(1):277–283CrossRefGoogle Scholar
  30. Ramineni SK, Cunningham LL, Dziubla TD, Puleo DA (2013) Development of imiquimod-loaded mucoadhesive films for oral dysplasia. J Pharm Sci 102(2):593–603CrossRefGoogle Scholar
  31. Ritger PL, Peppas NA (1987) A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs. J Controll Release 5(1):23–36CrossRefGoogle Scholar
  32. Serra L, Doménechc J, Peppas NA (2006) Drug transport mechanisms and release kinetics from molecularly designed poly(acrylic acid-g-ethylene glycol) hydrogels. Biomaterials 27(31):5440–5451CrossRefGoogle Scholar
  33. Siepmann J, Peppas NA (2012) Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev 64:163–174CrossRefGoogle Scholar
  34. Sizílio RH, Galvão JG, Trindade GGG, Pina LTS, Andrade LN, Gonsalves JKMC, Lira AAM, Chaud MV, Alves TFR, Arguelho MLPM, Nunes RS (2018) Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis. Carbohydr Polym 190:339–345CrossRefGoogle Scholar
  35. Soradech S, Limatvapirat S, Luangtana-anan M (2013) Stability enhancement of shellac by formation of composite film: effect of gelatin and plasticizers. J Food Eng 116(2):572–580CrossRefGoogle Scholar
  36. Sosnik A, Neves J, Sarmento B (2014) Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: a review. Prog Polym Sci 39:2030–2075CrossRefGoogle Scholar
  37. Talón E, Trifkovic KT, Vargas M, Chiralt A, González-Martínez C (2017) Release of polyphenols from starch-chitosan based films containing thyme extract. Carbohydr Polym 175:122–130CrossRefGoogle Scholar
  38. Tang L, Huang B, Lu Q, Wang S, Ou W, Lin W, Chen X (2013) Ultrasonication-assisted manufacture of cellulose nanocrystals esterified with acetic acid. Bioresour Technol 127:100–105CrossRefGoogle Scholar
  39. Wang J, Chen L, He Y (2008) Preparation of environmental friendly coatings based on natural shellac modified by diamine and its applications for copper protection. Progr Organ Coat 62(3):307–312CrossRefGoogle Scholar
  40. Wang K, Wen H, Yu D, Yang Y, Zhang D (2018) Electrosprayed hydrophilic nanocomposites coated with shellac for colon-specific delayed drug delivery. Mater Des 143(5):248–255CrossRefGoogle Scholar
  41. Wu X, Desai KH, Mallery SR, Holpuch AS, Phelps MP, Schwendeman SP (2012) Mucoadhesive fenretinide patches for site-specific chemoprevention of oral cancer: enhancement of oral mucosal permeation of fenretinide by coincorporation of propylene glycol and menthol. Mol Pharm 9:937–945CrossRefGoogle Scholar
  42. Yang C, Wang Y, Lu L, Unsworth L, Guan L, Chen L (2018) Oat protein-shellac beads: superior protection and delivery carriers for sensitive bioactive compounds. Food Hydrocolloids 77:754–763CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Jinshan CollegeFujian Agriculture and Forestry UniversityFuzhou CityChina
  2. 2.College of Material EngineeringFujian Agriculture and Forestry UniversityFuzhou CityChina

Personalised recommendations