Chitosan nanoparticles as a potential drug delivery system attached to viscose cellulose fibers
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Chitosan and its water-soluble N,N,N-trimethyl derivative were attached to cellulose fibers in the form of nanoparticle dispersions. The attachment of the chitosan nanoparticles to the fiber surface was studied by evaluation of the quantity of chitosan amino groups using a conventional spectrophotometric method supported by X-ray photoelectron spectroscopy. The desorption kinetics of the chitosan nanoparticles from the fiber surface was also examined indirectly by the spectrophotometric method. Additionally, a model drug was incorporated into the optimal chitosan nanoparticles for subsequent attachment to fibers to create a potential fibrous drug delivery system aimed at gynecological use, i.e., tampons as antimicrobial agents themselves or as drug reservoirs.
KeywordsChitosan Water-soluble N,N,N-trimethyl chitosan derivative Cellulose viscose fibers Adsorption/desorption Drug delivery system
The research work was produced within the framework of Project No. J2-7413 Multifunctional electrospunned nanofibers’ development and dynamic interaction studies with pathogen bacteria and Research Program P2-0118 TEXTILE CHEMISTRY, supported financially by the Slovenian Research Agency.
- Fras Zemljič L, Ristić T, Tkavc T (2012) Adsorption and antibacterial activity of soluble and precipitated chitosan on cellulose viscose fibers. J Eng Fiber Fabr 7(1):50–57Google Scholar
- Harvey D (2000) Spectroscopic methods of analysis in modern analytical chemistry. McGraw-Hill, New YorkGoogle Scholar
- Hirnle L, Heimrath J, Woyton J, Klosek A, Hirnle G, Malolepsza-Jarmolowska K (2001) Application of 2% clindamycin cream in the treatment of bacterial vaginosis and valuation of methylcellulose gel containing the complex of Chitosan F and PVP k-90 with lactic acid as carrier for intravaginally adhbited medicines in the cases of pregnancies with the symptoms of preterm delivery. Ginekol Pol 72:1096–1100Google Scholar
- King M (2016) Tampon market to achieve value of $2.65 billion by 2017. TransWorldNews. http://www.companiesandmarkets.com/News/Consumer-Goods/Tampon-market-to-achieve-value-of-2-65-billion-by-2017/NI3429. Accessed 19 Apr 2016
- Panwar P, Pandey B, Lakhera PC, Singh KP (2010) Preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes. Int J Nanomed 5:101–108Google Scholar
- PerkinElmer Inc. The 30-minute guide to ICP-MS—technical note, ICP-Mass Spectrometry PerkinElmer, Inc., Waltham, USA 2004–2011Google Scholar
- Ristić T, Fras Zemljič L, Zabret A, Strnad S (2012) Characterization and applications of nanostructured materials and nanotechnology. In: Obradović B (ed) First international conference processing. NanoBelgrade, Tehnološko-metalurški fakultet, Beograd, p 72Google Scholar
- Wazed SA, Joshi M, Rajendran S (2011) Novel, self assembled antimicrobial textile coating containing chitosan nanoparticles. AATCC Rev 11:49–55Google Scholar