, Volume 23, Issue 1, pp 749–763 | Cite as

Construction of cellulose/nanosilver sponge materials and their antibacterial activities for infected wounds healing

  • Dongdong Ye
  • Zibiao Zhong
  • Hui Xu
  • Chunyu ChangEmail author
  • Zixuan Yang
  • Yanfeng Wang
  • Qifa Ye
  • Lina ZhangEmail author
Original Paper


Antibacterial sponges with the silver nanoparticles (Ag NPs) were constructed by freeze-drying of cellulose composite hydrogels, which were prepared in NaOH/urea aqueous system with cooling, where the interconnecting pores of the sponge not only were used as micro-reactors to synthesize Ag nanoparticles but also inhibited the aggregation of Ag NPs. The Ag nanoparticles with size range from 4 to 50 nm, depending on the AgNO3 concentration, were uniformly immobilized in the cellulose/nanosilver sponges. The cellulose/nanosilver composite materials exhibited excellent antibacterial activities. Further, in vivo tests confirmed that the composite sponges had an ability to accelerate infected wound healing, as a result of the existence of the antibacterial Ag nanoparticles and absorbing capacity for wound exudate. The experimental data strongly encouraged the use of cellulose/nanosilver composite sponge as antibacterial materials, especially in case of serious wound infection. The composite cellulose sponge containing Ag nanoparticles provided an alternative material for the application of the infected wound healing.


Cellulose Sponge Silver nanoparticles Antibacterial activities Infected wound healing 



This work was supported by the National Basic Research Program of China (973 Program, 2010CB732203), the Major Program of Natural Science Foundation of China (21334005), and the National Natural Science Foundation of China (20874079 and 21304021).


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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Dongdong Ye
    • 1
  • Zibiao Zhong
    • 2
  • Hui Xu
    • 1
  • Chunyu Chang
    • 1
    Email author
  • Zixuan Yang
    • 2
  • Yanfeng Wang
    • 2
  • Qifa Ye
    • 2
  • Lina Zhang
    • 1
    Email author
  1. 1.College of Chemistry and Molecular SciencesWuhan UniversityWuhanChina
  2. 2.Zhongnan Hospital of Wuhan UniversityInstitute of Hepatobiliary Diseases of Wuhan UniversityWuhanChina

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