Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials
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In this paper, the use of ultrathin cellulose supports as platform for the incorporation of analgesic drugs in wound dressings is proposed. As a model drug, diclofenac (DCF) is chosen, which is commonly used in pain easing medical treatments. The DCF containing cellulose films are prepared by mixing solutions of trimethylsilyl cellulose (DSSi:2.5) with DCF dissolved in THF. After depositing the material on a solid surface by spin-coating, the films are subjected to vapor-phase hydrolysis using 3 M HCl in order to achieve regeneration of cellulose. The release of DCF from these films over time is studied by UV–Vis. Upon deposition of additional layers of cellulose that do not contain DCF, the release from these films can be decelerated significantly. The release kinetics from these films is very similar to those of viscose fibers impregnated with DCF solutions. These studies indicate a potential use of cellulose thin films as model platform for viscose based wound dressings.
KeywordsCellulose Model platform Wound dressings TMSC Diclofenac Release studies
The paper was co-produced within the framework of the operation entitled “Centre of Open innovation and ResEarch UM (CORE@UM)”. The operation is co-funded by the European Regional Development Fund and conducted within the framework of the Operational Programme for Strengthening Regional Development Potentials for the period 2007–2013, development priority 1: “Competitiveness of companies and research excellence”, priority axis 1.1: “Encouraging competitive potential of enterprises and research excellence”, contact No. 3330-13-500032. The authors acknowledge the financial support from the Ministry of Higher Education, Science and Technology of the Republic of Slovenia and thank the Christian Doppler research association and the Austrian Ministry of Economics, Family and Youth (BMWFJ) for financial support.
Conflict of interest
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