Cellulose

, Volume 21, Issue 4, pp 2647–2663

A novel synergistic formulation between a cationic surfactant from lysine and hyaluronic acid as an antimicrobial coating for advanced cellulose materials

  • Matej Bračič
  • Lourdes Pérez
  • Rosa Infante Martinez-Pardo
  • Ksenija Kogej
  • Silvo Hribernik
  • Olivera Šauperl
  • Lidija Fras Zemljič
Original Paper

Abstract

In this investigation, a novel coating for viscose fabric surface modification was developed using a synergistic formulation between a natural antimicrobial cationic surfactant from lysine (MKM) and a biopolymer hyaluronic acid (HA). The interaction between MKM and HA in aqueous solutions, as well as the interactions between their synergistic formulation (HA-MKM) and viscose fabric (CV) were studied using pH-potentiometric titrations’, turbidity measurements, the Kjeldahl method for the determination of nitrogen amounts, attenuated total reflectance fourier transform infrared spectroscopy, and scanning electron microscopy. The hydrophilic and antimicrobial properties of the functionalised CV were examined in order to evaluate its usages for medical applications. The results of the interaction studies showed that MKM and HA interact with each other by forming a precipitate when the binding sites of HA are saturated. The precipitate has a slightly positive charge at neutral pH due to excess binding of the MKM to HA. The excess positive charge was also detected on CV coated with HA-MKM. This was proven to be very beneficial for the antimicrobial properties of the functionalised CV. The antimicrobial tests showed exceptional antimicrobial activity of the functionalised CV against Escherichia Coli, StaphylococcusAureus, StreptococcusAgalactiae, Candida Albicans, and Candida Glabrata, making the CV fabric highly interesting for potential use in medicine.

Keywords

Viscose Hyaluronic acid Natural cationic surfactant pH-potentiometric titration Antimicrobial activity 

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Matej Bračič
    • 1
    • 2
  • Lourdes Pérez
    • 3
  • Rosa Infante Martinez-Pardo
    • 3
  • Ksenija Kogej
    • 4
  • Silvo Hribernik
    • 2
  • Olivera Šauperl
    • 2
  • Lidija Fras Zemljič
    • 2
  1. 1.Savatech d.o.o., Industrial Rubber Products and TyresKranjSlovenia
  2. 2.Institute for the Engineering and Design of MaterialsUniversity of MariborMariborSlovenia
  3. 3.Departamento de Tecnología de Tensioactivos, Instituto de Química Avanzada de CataluñaCSICBarcelonaSpain
  4. 4.Chair of Physical Chemistry, Faculty of Chemistry and Chemical TechnologyUniversity of LjubljanaLjubljanaSlovenia

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