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Cellulose

, Volume 21, Issue 3, pp 1431–1444 | Cite as

Structure characterizations and protein resistance of chitosan membranes selectively crosslinked by poly(ethylene glycol) dimethacrylate

  • Chia-Chu Cheng
  • Fwu-Long Mi
  • Shan-hui Hsu
  • Trong-Ming Don
Original Paper
  • 331 Downloads

Abstract

Chitosan (CS) is a fragile material with a high modulus of elasticity. Improving its flexibility as well as membrane permeability are the key aspects that need to be addressed for using CS as a biomaterial. Poly(ethylene glycol) (PEG) has several unique properties such as protein resistance, low toxicity, immunogenicity, and good solubility in both water and organic solvents. In this study, a vinyl compound was grafted to the C-6 position of CS by protection-grafting-deprotection. The vinyl CS was then crosslinked with PEG dimethacrylate (PEGDMA) selectively at its C-6 position to form CS-g-PEG copolymer membranes. Analyses from spectra of Fourier-transform infrared and nuclear magnetic resonance confirmed the chemical structure of the crosslinking CS-g-PEG copolymer membranes. Thermal and mechanical properties of the prepared CS-g-PEG membranes were measured and well-correlated to their structures. The incorporation of PEGDMA into the CS increased the material’s flexibility and thermal resistance. Finally, the CS-g-PEG membranes were found to have good protein resistance and blood compatibility; therefore, it has potential application as the biomedical material especially for hemodialysis.

Keywords

Chitosan Poly(ethylene glycol) dimethacrylate Copolymer membrane Protein resistance 

Notes

Acknowledgments

The authors wish to express their appreciation for the financial support from the National Science Council in Taiwan. The authors also want to thank Ms. Ching-Wei Lu in National Taiwan University for the help on the elemental analysis.

Supplementary material

10570_2014_231_MOESM1_ESM.docx (283 kb)
Supplementary material 1 (DOCX 283 kb)
10570_2014_231_MOESM2_ESM.docx (176 kb)
Supplementary material 2 (DOCX 175 kb)

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Chia-Chu Cheng
    • 1
  • Fwu-Long Mi
    • 2
    • 3
  • Shan-hui Hsu
    • 4
  • Trong-Ming Don
    • 1
  1. 1.Department of Chemical and Materials EngineeringTamkang UniversityNew Taipei CityTaiwan
  2. 2.Department of Biochemistry, School of MedicineTaipei Medical UniversityTaipeiTaiwan
  3. 3.Graduate Institute of Medical Sciences, College of MedicineTaipei Medical UniversityTaipeiTaiwan
  4. 4.Institute of Polymer Science and EngineeringNational Taiwan UniversityTaipeiTaiwan

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