Cell Biology and Toxicology

, Volume 32, Issue 3, pp 199–207 | Cite as

Telocytes of the human adult trigeminal ganglion

  • Mugurel Constantin Rusu
  • Dragos Cretoiu
  • Alexandra Diana Vrapciu
  • Sorin Hostiuc
  • Dan Dermengiu
  • Vasile Sorin Manoiu
  • Sanda Maria Cretoiu
  • Nicolae Mirancea
Article

Abstract

Telocytes (TCs) are typically defined as cells with telopodes by their ultrastructural features. Their presence was reported in various organs, however little is known about their presence in human trigeminal ganglion. To address this issue, samples of trigeminal ganglia were tested by immunocytochemistry for CD34 and examined by transmission electron microscopy (TEM). We found that TCs are CD34 positive and form networks within the ganglion in close vicinity to microvessels and nerve fibers around the neuronal–glial units (NGUs). TEM examination confirmed the existence of spindle-shaped and bipolar TCs with one or two telopodes measuring between 15 to 53 μm. We propose that TCs are cells with stemness capacity which might contribute in regeneration and repair processes by: modulation of the stem cell activity or by acting as progenitors of other cells present in the normal tissue. In addition, further studies are needed to establish if they might influence the neuronal circuits.

Keywords

Telocytes Telopodes CD34 Trigeminal ganglion Extracellular vesicles 

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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Mugurel Constantin Rusu
    • 1
    • 2
    • 3
  • Dragos Cretoiu
    • 4
    • 5
  • Alexandra Diana Vrapciu
    • 1
  • Sorin Hostiuc
    • 6
  • Dan Dermengiu
    • 6
    • 7
  • Vasile Sorin Manoiu
    • 8
  • Sanda Maria Cretoiu
    • 4
    • 5
  • Nicolae Mirancea
    • 9
  1. 1.Division of Anatomy, Faculty of Dental MedicineCarol Davila University of Medicine and PharmacyBucharestRomania
  2. 2.International Society of Regenerative Medicine and Surgery (ISRMS)BucharestRomania
  3. 3.MEDCENTER – Center of Excellence in Laboratory Medicine and PathologyBucharestRomania
  4. 4.Division of Cellular and Molecular Biology and Histology, Department 2 Morphological Sciences, Faculty of MedicineCarol Davila University of Medicine and PharmacyBucharestRomania
  5. 5.Victor Babes National Institute of PathologyBucharestRomania
  6. 6.Division of Legal Medicine and Bioethics, Department 2 Morphological Sciences, Faculty of MedicineCarol Davila University of Medicine and PharmacyBucharestRomania
  7. 7.Department of Forensic Pathology, National Institute of Legal MedicineBucharestRomania
  8. 8.Department of Cellular and Molecular BiologyNational Institute of Research and Development for Biological SciencesBucharestRomania
  9. 9.Institute of Biology of BucharestThe Romanian AcademyBucharestRomania

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