Telocytes of the human adult trigeminal ganglion
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Telocytes (TCs) are typically defined as cells with telopodes by their ultrastructural features. Their presence was reported in various organs, however little is known about their presence in human trigeminal ganglion. To address this issue, samples of trigeminal ganglia were tested by immunocytochemistry for CD34 and examined by transmission electron microscopy (TEM). We found that TCs are CD34 positive and form networks within the ganglion in close vicinity to microvessels and nerve fibers around the neuronal–glial units (NGUs). TEM examination confirmed the existence of spindle-shaped and bipolar TCs with one or two telopodes measuring between 15 to 53 μm. We propose that TCs are cells with stemness capacity which might contribute in regeneration and repair processes by: modulation of the stem cell activity or by acting as progenitors of other cells present in the normal tissue. In addition, further studies are needed to establish if they might influence the neuronal circuits.
KeywordsTelocytes Telopodes CD34 Trigeminal ganglion Extracellular vesicles
This work was partially supported by grants of the Romanian National Authority for Scientific Research, CNCS—UEFISCDI, project numbers 82/2012 and 194/2014.
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Conflicts of interest
The authers declare that they have no conflicts of interest.
- Bei Y, Wang F, Yang C, Xiao J. Telocytes in regenerative medicine. J Cell Mol Med. 2015a.Google Scholar
- Cretoiu D, Cretoiu SM. Telocytes in the reproductive organs: current understanding and future challenges. Semin Cell Dev Biol. 2016.Google Scholar
- Diaz-Flores L, Gutierrez R, Garcia MP, Saez FJ, Diaz-Flores Jr L, Valladares F, et al. CD34+ stromal cells/fibroblasts/fibrocytes/telocytes as a tissue reserve and a principal source of mesenchymal cells. Location, morphology, function and role in pathology. Histol Histopathol. 2014;29:831–70.PubMedGoogle Scholar
- Diaz-Flores L, Gutierrez R, Garcia MP, Gonzalez M, Diaz-Flores L Jr, Madrid JF. Telocytes as a source of progenitor cells in regeneration and repair through granulation tissue. Curr Stem Cell Res Ther. 2015aGoogle Scholar
- Diaz-Flores L, Gutierrez R, Diaz-Flores L, Gomez MG Jr, Saez FJ, Madrid JF. Behaviour of telocytes during physiopathological activation. Semin Cell Dev Biol. 2016.Google Scholar
- Ibba-Manneschi L, Rosa I, Manetti M. Telocyte implications in human pathology: an overview. Semin Cell Dev Biol. 2016Google Scholar
- Manole CG, Gherghiceanu M, Simionescu O. Telocyte dynamics in psoriasis. J Cell Mol Med. 2015Google Scholar
- Popescu LM, Fertig ET, Gherghiceanu M. Reaching out: junctions between cardiac telocytes and cardiac stem cells in culture. J Cell Mol Med. 2015.Google Scholar
- Rusu MC. Skin telopodes. Romanian J Morphol Embryol = Rev Roum Morphol Embryol. 2014;55:723–4.Google Scholar
- Rusu MC, Mănoiu VM, Mirancea N, Nini G. Quiescent satellite glial cells of the adult trigeminal ganglion. Cent Eur J Med. 2014c;9:500–4.Google Scholar
- Song D, Cretoiu D, Zheng M, Qian M, Zhang M, Cretoiu SM, et al. Comparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types. J Cell Mol Med. 2015Google Scholar
- Sun X, Zheng M, Zhang M, Qian M, Zheng Y, Li M, et al. Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes. J Cell Mol Med. 2014;18:801–10.CrossRefPubMedPubMedCentralGoogle Scholar
- Vannucchi MG, Bani D, Faussone-Pellegrini M-S. Telocytes contribute as cell progenitors and differentiation inductors in tissue regeneration. Curr Stem Cell Res Ther. 2015Google Scholar
- Yang J, Chi C, Liu Z, Yang G, Shen ZJ, Yang XJ. Ultrastructure damage of oviduct telocytes in rat model of acute salpingitis. J Cell Mol Med. 2015Google Scholar