Cell Biology and Toxicology

, Volume 29, Issue 4, pp 199–211 | Cite as

Mechanisms of proteasome inhibitor-induced cytotoxicity in malignant glioma

  • Panagiotis J. Vlachostergios
  • Ioannis A. Voutsadakis
  • Christos N. Papandreou
Review Article


The 26S proteasome constitutes an essential degradation apparatus involved in the consistent recycling of misfolded and damaged proteins inside cells. The aberrant activation of the proteasome has been widely observed in various types of cancers and implicated in the development and progression of carcinogenesis. In the era of targeted therapies, the clinical use of proteasome inhibitors necessitates a better understanding of the molecular mechanisms of cell death responsible for their cytotoxic action, which are reviewed here in the context of sensitization of malignant gliomas, a tumor type particularly refractory to conventional treatments.


Glioma Proteasome inhibitor Cytotoxicity Apoptosis Necrosis Autophagy 


Conflict of interest statement

There is no conflict of interest or financial support related to this article.


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© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Panagiotis J. Vlachostergios
    • 1
  • Ioannis A. Voutsadakis
    • 2
  • Christos N. Papandreou
    • 1
  1. 1.Department of Medical Oncology, Faculty of MedicineUniversity of Thessaly, University Hospital of LarissaLarissaGreece
  2. 2.Centre Pluridisciplinaire d’ OncologieCentre Hospitalier Universitaire VaudoisLausanneSwitzerland

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