Catalysis Letters

, Volume 141, Issue 5, pp 735–741 | Cite as

A One-Pot Two-Step Approach for the Catalytic Conversion of Glucose into 2,5-Diformylfuran

  • Xi Xiang
  • Ling He
  • Yu Yang
  • Bin Guo
  • Dongmei Tong
  • Changwei Hu


One-pot two-step synthesis of DFF was achieved by catalytic conversion of glucose over CrCl3·6H2O/NaBr//NaVO3·2H2O catalysts, and a DFF yield of 55% based on glucose was obtained. This glucose conversion process is characterized by the abundance and low cost of starting material and no need for HMF separation or purification.

Graphical Abstract

An alternative one-pot one-step approach for the catalytic conversion of glucose into DFF with a yield of 18% in the CrCl3·6H2O/NaBr//NaVO3·2H2O system has been reported for the first time. Two-step process can give higher DFF yield than one-step, and the best DFF yield of 55% can be obtained under mild reaction conditions.


Glucose Dehydration 5-Hydroxymethlfurfural 2,5-Diformylfuran Oxidation 

Supplementary material

10562_2011_555_MOESM1_ESM.doc (136 kb)
Supplementary material 1 (DOC 136 kb)


  1. 1.
    Lewkowski J (2001) Arkivoc 1:17Google Scholar
  2. 2.
    Tong XL, Ma Y, Li YD (2010) Appl Catal A Gen 385:1CrossRefGoogle Scholar
  3. 3.
    Hopkins KT, Wilson WD, Bender BC, McCurdy DR, Hall JE, Tidwell RR, Kumar A, Bajic M, Boykin DW (1998) J Med Chem 41:3872CrossRefGoogle Scholar
  4. 4.
    Del Poeta M, Schell WA, Dykstra CC, Jones S, Tidwell RR, Czarny A, Bajic M, Kumar A, Boykin D, Perfect JR (1998) Antimicrob Agents Chemother 42:2495Google Scholar
  5. 5.
    Richter DT, Lash TD (1999) Tetrahedron Lett 40:6735CrossRefGoogle Scholar
  6. 6.
    Howarth OW, Morgan GG, McKee V, Nelson J (1999) J Chem Soc Dalton Trans 12:2097CrossRefGoogle Scholar
  7. 7.
    Sheibley DW, Manzo MA, Gonzalez-Sanabria OD (1983) J Electrochem Soc 130:255CrossRefGoogle Scholar
  8. 8.
    Amarasekara AS, Green D, Williams LD (2009) Eur Polym J 45:595CrossRefGoogle Scholar
  9. 9.
    Gandini A, Belgacem NM (1998) Polym Int 47:267CrossRefGoogle Scholar
  10. 10.
    Verdeguer P, Merat N, Gaset A (1993) J Mol Catal 85:327CrossRefGoogle Scholar
  11. 11.
    Partenheimer W, Grushin VV (2001) Adv Synth Catal 343:102CrossRefGoogle Scholar
  12. 12.
    Moreau C, Durand R, Pourcheron C, Tichit D (1997) Stud Surf Sci Catal 108:399CrossRefGoogle Scholar
  13. 13.
    Carlini C, Patrono P, Raspolli AM, Sbrana G, Zima V (2005) Appl Catal A Gen 289:197CrossRefGoogle Scholar
  14. 14.
    Amarasekara AS, Green D, McMillan E (2008) Catal Commun 9:286CrossRefGoogle Scholar
  15. 15.
    Navarro OC, Canós AC, Chornet SI (2009) Top Catal 52:304CrossRefGoogle Scholar
  16. 16.
    Chheda JN, Huber GW, Dumesic JA (2007) Angew Chem Int Ed 46:7164CrossRefGoogle Scholar
  17. 17.
    Lichtenthaler FW (2002) Acc Chem Res 35:728CrossRefGoogle Scholar
  18. 18.
    Binder JB, Raines RD (2009) J Am Chem Soc 131:1979CrossRefGoogle Scholar
  19. 19.
    Yong G, Zhang YG, Ying JY (2008) Angew Chem Int Ed 47:9345CrossRefGoogle Scholar
  20. 20.
    Halliday GA, Young RJ, Grushin VV (2003) Org Lett 5:2003CrossRefGoogle Scholar
  21. 21.
    Choudary BM, Kantam ML, Neeraja V, Bandyopadhyay T, Reddy P (1999) J Mol Catal A Chem 140:25CrossRefGoogle Scholar
  22. 22.
    Sweeley CC, Bentley R, Makita M, Wells WW (1963) J Am Chem Soc 85:2497CrossRefGoogle Scholar
  23. 23.
    Zhu LF, Guo B, Tang DY, Hu XK, Li GY, Hu CW (2007) J Catal 245:446CrossRefGoogle Scholar
  24. 24.
    Sri H, Rigal L, Gaset A (1992) FR Patent 2669636Google Scholar
  25. 25.
    Szmant HH, Chundury DD (1981) J Chem Tech Biotechnol 31:135CrossRefGoogle Scholar
  26. 26.
    Ohara M, Takagaki A, Nishimura S, Ebitani K (2010) Appl Catal A Gen 383:149CrossRefGoogle Scholar
  27. 27.
    Román-Leshkov Y, Chheda JN, Dumesic JA (2006) Science 312:1933CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Xi Xiang
    • 1
  • Ling He
    • 1
  • Yu Yang
    • 1
  • Bin Guo
    • 1
  • Dongmei Tong
    • 1
  • Changwei Hu
    • 1
  1. 1.Key Laboratory of Green Chemistry and Technology, Ministry of EducationCollege of Chemistry, Sichuan UniversityChengduPeople’s Republic of China

Personalised recommendations