Catalysis Letters

, Volume 122, Issue 3–4, pp 310–313 | Cite as

Chloroferrate(III) Ionic Liquid: Efficient and Recyclable Catalyst for Solvent-free Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones

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Abstract

A water-tolerant Lewis acidic ionic liquid, [bmim][FeCl4], was found to be an efficient and recyclable catalyst in the synthesis of 4-aryl-dihydropyrimidinones through Biginelli condensation. This method is capable of being scaled up, if desired.

Keywords

Biginelli reaction Dihydropyrimidinones Ionic liquid Lewis acid Green chemistry 
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Notes

Acknowledgments

Financial support for this work from the National Basic Research Program of China (2003CB114402), National Key Technology R&D Program of China (2006BAE01A01-8), and Shanghai Educational Committee are gratefully acknowledged.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.Shanghai Key Laboratory of Chemical Biology, School of PharmacyEast China University of Science & TechnologyShanghaiP.R. China

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