Adipose-derived mesenchymal stem cell exosomes: a novel pathway for tissues repair
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The well-characterized curative effect of transplanted mesenchymal stem cells has been mainly attributed to their homing and subsequent differentiation for the repair and regeneration of damaged tissue. Adipose-derived mesenchymal stem cells (ADMSCs) are not only multipotent and plastic, but also abundant as they can be easily harvested with minimally invasive surgical techniques. This makes ADMSCs conducive for clinical applications. Recently, the secretory function of ADMSCs has been regarded as the primary mediator of MSC-based therapy. Exosomes are one kind of small cell extracellular membrane vesicles, which are primarily used to deliver cell-specific proteins, as well as nucleic acids secreted by various cell types. This review will introduce and characterize exosomes-derived ADMSCs (ADMSCs-Exo) and look at new therapies and prospective, including the limitations and outlook for therapeutic strategy. We will describe the latest research progress on myocardial repair, neuroprotection and neurotrophic effects, hepatic repair, renal repair, cutaneous repair, regeneration and other aspects using these cells.
KeywordsAdipose-derived mesenchymal stem cell Exosomes Tissues repair mechanism
Compliance with ethical standards
This article does not contain any studies with human participants or animals performed by any of the authors.
- Chen HH et al (2014b) Melatonin augments apoptotic adipose-derived mesenchymal stem cell treatment against sepsis-induced acute lung injury. Am J Transl Res 6:439Google Scholar
- Chen KH et al (2016) Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke. Oncotarget 7:74537–74556Google Scholar
- Dominici M et al (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. Int Soc Cell Ther Position Statement Cytotherapy 8:315Google Scholar
- Kim MH, Koh SO, Kim EJ, Jin SC, Na SW (2015) Incidence and outcome of contrast-associated acute kidney injury assessed with risk, injury, failure, loss, and end-stage kidney disease (RIFLE) criteria in critically ill patients of medical and surgical intensive care units: a retrospective study. BMC Anesthesiol 15(1):23CrossRefGoogle Scholar
- Ko SF et al (2015) Adipose-derived mesenchymal stem cell exosomes suppress hepatocellular carcinoma growth in a rat model: apparent diffusion coefficient natural killer T-cell responses, and histopathological features. Stem Cells Int 2015:853506. https://doi.org/10.1155/2015/853506 CrossRefGoogle Scholar
- Mendez-Ferrer S et al (2009) Coordinated regulation of hematopoietic and mesenchymal stem cells in a bone marrow niche. Blood 114(22):3Google Scholar
- Zhu F et al (2017) Adipose-derived mesenchymal stem cells employed exosomes to attenuate AKI-CKD transition through tubular epithelial cell dependent Sox9 activation. Oncotarget 8:70707–70726Google Scholar