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Cell and Tissue Banking

, Volume 19, Issue 4, pp 645–651 | Cite as

Cadaver skin allograft may improve mortality rate for burns involving over 30% of total body surface area: a propensity score analysis of data from four burn centers

  • Young Hwan Choi
  • Young Soon Cho
  • Jong Ho Lee
  • Yanghwan Choi
  • Soo Young Noh
  • Seungchoon Park
  • Changmin Sung
  • Jin Kyu Lim
  • Jongdae Kim
  • Jae Jun Shin
  • Banseok Yang
  • Jiyun Jeong
  • Huan Chun
  • Kwang Jo Kim
Article
  • 51 Downloads

Abstract

Cadaver skin is used for temporary wound covering, but there is insufficient evidence regarding its clinical usefulness in patients with major burns. We aimed to analyze the effect of cadaveric skin allograft on mortality rates in patients with burns involving > 30% of total body surface area (TBSA). Our study included 1282 patients with > 30% of TBSA burned admitted to four hospitals in Korea between June 1, 2008 and December 31, 2016. Of these, 698 patients underwent cadaver skin allograft (cadaver group), and 584 were treated with conventional treatment (non-cadaver group). We corrected the differences between the two groups using propensity score matching, and generated 474 propensity score-matched pairs. Overall 90-day in-hospital mortality rate among all patients was 35.3% (453/1282). There was a significant difference in 90-day in-hospital mortality between the two groups for both unmatched [cadaver vs. conventional, 31.7 vs. 39.7%; difference, 8.0; 95% confidence interval (CI) 2.8–13.3] and propensity-matched groups (37.8 vs. 47.3%; difference, 9.5; 95% CI 3.2–15.8). Logistic regression analyses showed a significant association between cadaver skin allograft and lower 90-day in-hospital mortality in the propensity-matched groups (odds ratio, 0.42; 95% CI 0.29–0.62). Patients with major burns who underwent cadaver skin allograft had a lower mortality rate compared to those who did not. Cadaver skin allograft may improve the survival of patients with major burns, especially in the early phase of injury.

Keywords

Allograft Cadaver skin Major burn 

Notes

Acknowledgements

This work was supported by the Soonchunhyang University Research Fund.

Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflict of interest.

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  • Young Hwan Choi
    • 1
  • Young Soon Cho
    • 2
  • Jong Ho Lee
    • 1
  • Yanghwan Choi
    • 1
  • Soo Young Noh
    • 3
  • Seungchoon Park
    • 3
  • Changmin Sung
    • 1
  • Jin Kyu Lim
    • 3
  • Jongdae Kim
    • 3
  • Jae Jun Shin
    • 3
  • Banseok Yang
    • 3
  • Jiyun Jeong
    • 3
  • Huan Chun
    • 3
  • Kwang Jo Kim
    • 3
  1. 1.Department of Emergency MedicineBestian HospitalSeoulKorea
  2. 2.Department of Emergency MedicineSoonchunhyang University Bucheon HospitalBucheon-siKorea
  3. 3.Department of General SurgeryBestian HospitalSeoulKorea

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