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Cell and Tissue Banking

, Volume 19, Issue 3, pp 437–445 | Cite as

Organization model for allotransplantations of cryopreserved vascular grafts in Czech Republic

  • Miroslav ŠpačekEmail author
  • Pavel Měřička
  • Libor Janoušek
  • Petr Štádler
  • Miloš Adamec
  • Robert Vlachovský
  • Igor Guňka
  • Pavel Navrátil
  • Filip Thieme
  • Petr Mitáš
  • Rudolf Špunda
  • Jaroslav Špatenka
  • Robert Staffa
  • Petr Němec
  • Jaroslav Lindner
Article
  • 116 Downloads

Abstract

The transplantation of fresh or cryopreserved vascular allografts in patients with a prosthetic graft infection or critical limb ischemia is necessary for their limb salvage and, in many cases, represents a lifesaving procedure. While transplantation of fresh allografts has a long history in the Czech Republic, the standard use of cryopreserved vascular allografts was introduced into the clinical practice in 2011 as a result of the implementation of EU Directive 2004/23/EC into national legislation (Human Cell and Tissue Act No. 296/2008 Coll.). The authors present an organizational model based on cooperation between the majority of Czech Transplant Centers with a tissue establishment licensed by the national competent authority. In various points, we are addressing individual aspects of experimental and clinical studies which affect clinical practice. Based on experimental and clinical work, the first validation of cryopreserved arterial and venous grafts for clinical use was performed between 2011 and 2013. The growing number of centers participating in this programme led to a growing number of patients who underwent transplantation of vascular allografts. In 2015 the numbers of transplanted fresh versus cryopreserved allografts in the Czech Republic were almost equal. Cooperation of the participating centers in the Czech Republic with the licensed Tissue Establishment made it possible to achieve a full compliance with the European Union Directives, and harmonized national legal norms and assured a high quality of cryopreserved vascular allografts.

Keywords

Vascular allograft Cryopreservation Tissue transplantation Organization model 

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Miroslav Špaček
    • 1
    Email author
  • Pavel Měřička
    • 2
  • Libor Janoušek
    • 3
  • Petr Štádler
    • 4
  • Miloš Adamec
    • 10
  • Robert Vlachovský
    • 5
  • Igor Guňka
    • 6
    • 7
  • Pavel Navrátil
    • 7
  • Filip Thieme
    • 3
  • Petr Mitáš
    • 1
  • Rudolf Špunda
    • 1
  • Jaroslav Špatenka
    • 9
  • Robert Staffa
    • 5
  • Petr Němec
    • 8
  • Jaroslav Lindner
    • 1
  1. 1.2nd Department of Surgery - Department of Cardiovascular Surgery, First Faculty of MedicineCharles University in Prague and General University Hospital in PraguePragueCzech Republic
  2. 2.Tissue BankUniversity Hospital Hradec KrálovéHradec KrálovéCzech Republic
  3. 3.Department of Transplant SurgeryInstitute for Clinical and Experimental MedicinePragueCzech Republic
  4. 4.Department of Vascular SurgeryNa Homolce HospitalPragueCzech Republic
  5. 5.2nd Department of Surgery, St. Anne’s University Hospital, Faculty of MedicineMasaryk UniversityBrnoCzech Republic
  6. 6.Department of Surgery, University Hospital and Faculty of Medicine Hradec KraloveCharles University in PragueHradec KraloveCzech Republic
  7. 7.Transplant Center, University Hospital and Faculty of Medicine Hradec KraloveCharles University in PragueHradec KraloveCzech Republic
  8. 8.Center of Cardiovascular Surgery and Transplantations BrnoBrnoCzech Republic
  9. 9.Department of Transplantation and Tissue BankUniversity Hospital MotolPragueCzech Republic
  10. 10.Transplants Coordinating CentrePragueCzech Republic

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