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Mesenchymal stem cells for chronic wounds therapy

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Abstract

Wound healing is a complex process that involves interaction of soluble mediators, extracellular matrix and infiltrating blood cells. Chronic and non-healing skin defects contribute significantly to morbidity and mortality of many patients. Recently, despite the current medical progress, the chronic and non-healing wounds still represent a serious medical problem. In many cases, conventional therapeutic approaches, such as dermal substitutes and growth factor therapy failed and do not produce the expected results, patients are exposed to a high risk of infection, sepsis or amputation. For that reason clinicians and researchers are forced to searching for alternative methods to induce healing process which may result into complete wound closure. Mesenchymal stem cells (MSCs) represent a unique tool of tissue engineering and regenerative medicine and a promising therapeutic strategy. Due to their unique biological properties, MSCs seem to be the perspective modality method for these patients. Many preclinical and clinical studies suggest the possibility of using these cells in tissue regeneration, healing acute and chronic wounds and scar remodelling. The objective of the present review is to summarize the current information and preclinical data about MSCs, their biological characteristics and mode of action during regenerative and healing processes, as well as their clinical application in chronic wounds treatment.

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Acknowledgments

The study was supported by the Ministry of Health of the Slovak Republic under the project No. 2012/4-UKBA-4 and partly by Grant APVV No. 0434-12.

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Authors and Affiliations

  1. Department of Burns and Reconstructive Surgery, Faculty of Medicine, Comenius University in Bratislava, Pazitkova 4, 821 01, Bratislava, Slovakia

    Peter Zahorec & Jan Koller

  2. University Hospital, Bratislava, Slovakia

    Peter Zahorec, Jan Koller & Martin Bohac

  3. Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, Comenius University in Bratislava, Pazitkova 4, 821 01, Bratislava, Slovakia

    Martin Bohac

  4. Faculty of Medicine, Institute of Medical Biology, Genetics and Clinical Genetics, Comenius University in Bratislava, Sasinkova 4, 811 08, Bratislava, Slovakia

    Lubos Danisovic

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  1. Peter Zahorec
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  2. Jan Koller
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  3. Lubos Danisovic
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  4. Martin Bohac
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Correspondence to Martin Bohac.

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Peter Zahorec and Martin Bohac have contributed equally and to be considered as equal first authors.

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Zahorec, P., Koller, J., Danisovic, L. et al. Mesenchymal stem cells for chronic wounds therapy. Cell Tissue Bank 16, 19–26 (2015). https://doi.org/10.1007/s10561-014-9440-2

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