Cell and Tissue Banking

, Volume 12, Issue 2, pp 105–110

Adeno-associated virus (AAV) based gene therapy for eye diseases

  • Shuang Wang
  • Peng Liu
  • Lei Song
  • Lei Lu
  • Wensong Zhang
  • Yazhen Wu
Article

DOI: 10.1007/s10561-011-9243-7

Cite this article as:
Wang, S., Liu, P., Song, L. et al. Cell Tissue Bank (2011) 12: 105. doi:10.1007/s10561-011-9243-7

Abstract

Gene therapy emerged as important approach in treatment for many inborn disorders caused by genetic defects, as well as other diseases. This manuscript focused on Adeno-associated virus (AAV) based gene therapy to eye diseases. The paper firstly introduced the AAV vectors and the techniques of eye delivery, then summarized some tested genes that were used in past treatment to retinal degeneration disorders. Finally the paper discussed the updated optogenetics and its roles in AAV based gene therapy for eye diseases.

Keywords

AAV Gene therapy Optogenetics Neovascularization Trophic factor Neuroprotection 

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Shuang Wang
    • 1
    • 2
  • Peng Liu
    • 2
  • Lei Song
    • 3
  • Lei Lu
    • 3
  • Wensong Zhang
    • 3
  • Yazhen Wu
    • 1
  1. 1.Department of OphthalmologyThe Second Hospital of Ji Lin UniversityJi LinChina
  2. 2.China-Japan Union Hospital of Jilin UniversityJi LinChina
  3. 3.Department of NeurologyThe First Hospital of Ji Lin UniversityJi LinChina

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