Cell and Tissue Banking

, Volume 10, Issue 3, pp 271–280 | Cite as

Organ and tissue safety workshop 2007: advances and challenges

  • Jay A. Fishman
  • D. Michael Strong
  • Matthew J. Kuehnert


A workshop in June 2005 (“Preventing Organ and Tissue Allograft-Transmitted Infection: Priorities for Public Health Intervention”) identified gaps in organ and tissue safety in the US. Participants developed a series of allograft safety initiatives. “The Organ and Tissue Safety Workshop 2007: Advances and Challenges” assessed progress and identified priorities for future interventions. Awareness of the challenges of allograft-associated disease transmission has increased. The Transplantation Transmission Sentinel Network will enhance communication surrounding allograft-associated disease transmission. Other patient safety initiatives have focused on adverse event reporting and microbiologic screening technologies. Despite progress, improved recognition and prevention of donor-derived transmission events is needed. This requires systems integration across the organ and tissue transplantation communities including organ procurement organizations, eye and tissue banks, and transplant infectious disease experts. Commitment of resources and improved coordination of efforts are required to develop essential tools to enhance safety for allograft recipients.


Transplantation Infectious disease transmission Tissue Organs Cornea Adverse events Surveillance 


  1. Basset D, Faraut F, Marty P, Dereure J, Rosenthal E, Mary C, Pratlong F, Lachaud L, Bastien P, Dedet JP (2005) Visceral leishmaniasis in organ transplant recipients: 11 new cases and a review of the literature. Microbes Infect 7:1370–1375. doi: 10.1016/j.micinf.2005.06.002 PubMedCrossRefGoogle Scholar
  2. Centers for Disease Control and Prevention (2001) Chagas disease after organ transplantation—United States, 2001. MMWR 51(10):210–212Google Scholar
  3. Centers for Disease Control and Prevention (2002) West Nile virus infection in organ donor and transplant recipients—Georgia and Florida. MMWR 51:790Google Scholar
  4. Centers for Disease Control and Prevention (2005) West Nile virus infections in organ transplant recipients—New York and Pennsylvania, August–September. MMWR 54(40):1021–1023Google Scholar
  5. Centers for Disease Control, Prevention (2008) Transplantation-transmitted tuberculosis—Oklahoma, Texas, 2007. MMWR 57(13):333–336Google Scholar
  6. Cortes NJ, Afzali B, MacLean D, Goldsmithe DJ, O’Sullivan H, Bingham J, Lewis DA, MacMahon E, Tong CY, Koffman G (2006) Transmission of syphilis by organ transplantation. Am J Transplant 6:2497–2499. doi: 10.1111/j.1600-6143.2006.01461.x PubMedCrossRefGoogle Scholar
  7. D’Albuquerque LA, Gonzalez AM, Filho HL, Coopstein JLM, Larrea FIS, Mansero JMP, Peron G, Ribeiro MAF, de Oliveira e Silva A (2007) Liver transplantation from deceased donors serologically positive for Chagas disease. Am J Transplant 7(3):680–684. doi: 10.1111/j.1600-6143.2007.01663.x PubMedCrossRefGoogle Scholar
  8. Eastlund T, Strong DM (2004) Infectious disease transmission through tissue transplantation. In: (Phillips GO (ed) Advances in tissue banking, vol 7. World Scientific Publishing Company, Singapore, pp 51–131Google Scholar
  9. Fischer SA, Graham MB, Kuehnert MJ et al (2006) Transmission of lymphocytic choriomeningitis virus by organ transplantation. N Engl J Med 354:2235–2249. doi: 10.1056/NEJMoa053240 PubMedCrossRefGoogle Scholar
  10. Fishman JA (2007) Infection in solid organ transplant recipients. N Engl J Med 357:2601–2614. doi: 10.1056/NEJMra064928 PubMedCrossRefGoogle Scholar
  11. Fishman JA (2008) Rapporto dell’OMS sulla valutazione del programma nazionale trapianti in Italia (gennaio 2008). Trapianti 12(2):37–53Google Scholar
  12. Fishman JA, Greenwald MA, Kuehnert MD (2007) Enhancing transplant safety: a new era in the microbiologic evaluation of organ donors? Am J Transplant 7:2652–2654. doi: 10.1111/j.1600-6143.2007.02023.x PubMedCrossRefGoogle Scholar
  13. Food and Drug Administration (2005) Procedures for handling adverse reaction reports related to ‘‘361’’ human cells, tissues, and cellular and tissue-based products (HCT/Ps). Accessed 28 July 2008
  14. Gandhi MJ, Strong DM (2007) Donor derived malignancy: a review. Cell Tissue Bank 8(4):267–286. doi: 10.1007/s10561-007-9036-1 PubMedCrossRefGoogle Scholar
  15. Guaraldi G, Cocchi S, Codeluppi M, Pecorari M, Barozzi P, Gennari W, Bagni A, Bosco R, Vallerini D, Di Benedetto F, Masetti M, Portolani M, Torelli G, Luppi M (2006) Giant cell hepatitis following primary infection with HHV-6 variant A, transmitted from the donor, in a liver transplant recipient latently infected with HHV-6 variant B. J Clin Virol 37(1):S108. doi: 10.1016/S1386-6532(06)70059-2 CrossRefGoogle Scholar
  16. Hassan SS, Wilhelmus KR, Dahl P, Davis GC, Roberts RT, Ross KW, Varnum BH, Medical Review Subcommittee of the Eye Bank Association of America (2008) Infect dis risk factors corneal graft donors. Arch Ophthalmol 126:235–239PubMedCrossRefGoogle Scholar
  17. Hellenbrand W, Meyer C, Rasch G, Steffens I, Ammon A (2005) Cases of rabies in Germany following organ transplantation. Euro Surveill 10:E050224PubMedGoogle Scholar
  18. Humar A, Fishman JA (2008) Donor-derived infection: old problem, new solutions? Am J Transplant 8(6):1087–1088. doi: 10.1111/j.1600-6143.2008.02246.x PubMedCrossRefGoogle Scholar
  19. JAMA (2005) Lymphocytic choriomeningitis virus infection in organ transplant recipients-Massachusetts, Rhode Island, 2005. JAMA 294(2):173–174. doi: 10.1001/jama.294.2.173 CrossRefGoogle Scholar
  20. Kainer MA, Linden JV, Whaley DN, Holmes HT, Jarvis WR, Jernigan DB, Archibald LK (2004) Clostridium infections associated with musculoskeletal-tissue allografts. N Engl J Med 350:2564–2571. doi: 10.1056/NEJMoa023222 PubMedCrossRefGoogle Scholar
  21. Kuehnert MJ, Clark E, Lockhart SR, Soll DR, Cilia J, Jarvis WR (1998) Candida albicans endocarditis associated with a contaminated aortic valve allograft: implications for regulation of allograft processing. Clin Infect Dis 27(4):688–691. doi: 10.1086/514944 PubMedCrossRefGoogle Scholar
  22. Kumar D, Drebot MA, Wong SJ et al (2004) A seroprevalence study of West Nile virus infection in solid organ transplant recipients. Am J Transplant 4:1883–1888. doi: 10.1111/j.1600-6143.2004.00592.x PubMedCrossRefGoogle Scholar
  23. Larsen M, Habermann TM, Bishop AT, Shin AY, Spinner RJ (2007) Epstein-Barr virus infection as a complication of transplantation of a nerve allograft from a living related donor. Case report. J Neurosurg 106:924–928. doi: 10.3171/jns.2007.106.5.924 Google Scholar
  24. Lee EH, Ferguson D, Jernigan D, Greenwald M, Cote T, Bos JE, Guarner J, Zaki S, Schuchat A, Beall B, Srinivasan A (2007) Invasive group-a streptococcal infection in an allograft recipient. A case report. J Bone Joint Surg Am 89:2044–2047. doi: 10.2106/JBJS.F.01594 PubMedCrossRefGoogle Scholar
  25. Martin-Davilla P, Fortun J, Lopez-Velez R, Norman F, de Oca MM, Zamarron P, Gonzalez MI, Moreno A, Fumarola T, Garrido G (2008) Transmission of tropical and geographically restricted infections during solid-organ transplantation. Clin Rev Microbiol 21:60–98. doi: 10.1128/CMR.00021-07 CrossRefGoogle Scholar
  26. OPTN (2007) OPTN/UNOS Statement regarding HIV and Hepatitis C Transmission through organ transplantation. Available via OPTN. Accessed 1 Sept 2008
  27. Palacios G, Druce J, Du L et al (2008) A new arenavirus in a cluster of fatal transplant-associated diseases. N Engl J Med 358:991–998. doi: 10.1056/NEJMoa073785 PubMedCrossRefGoogle Scholar
  28. Reuters (2007) Italian doctors transplant HIV infected organs. Available via Accessed 28 July 2008
  29. Schweitzer EJ, Perencevich EN, Philosophe B, Bartlett ST (2007) estimated benefits of transplantation of kidneys from donors at increased risk for HIV or Hepatitis C Infection. Am J Transplant 7:1515–1525. doi: 10.1111/j.1600-6143.2007.01769.x PubMedCrossRefGoogle Scholar
  30. Srinivasan A, Burtin EC, Kuehnert MJ, Rupprecht C, Sutker W, Ksiazek TG, Paddock CD, Guarner J, Shieh WJ, Goldsmith C, Hanlon CA, Zoretic J, Fischbach B, Niezgoda M, El-Feky WH, Orciari L, Sanchez EQ, Likos A, Klintmalm GB, Cardo D, Leduc J, Chamberland ME, Jernigan DB, Zaki SR (2005) Transmission of rabies virus from an organ donor to four transplant recipients. N Engl J Med 352:1103–1111. doi: 10.1056/NEJMoa043018 PubMedCrossRefGoogle Scholar
  31. Stramer SL, Caglioti S, Strong DM (2000) NAT of the United States and Canadian blood supply. Transfusion 50:1165–1168. doi: 10.1046/j.1537-2995.2000.40101165.x CrossRefGoogle Scholar
  32. Stramer SL, Glynn SA, Kleinman SH, Strong DM, Caglioti S, Wright DJ, Dodd RY, Busch MP (2004) Detection of HIV-1 and HCV infections among antibody-negative blood donors by nucleic acid-amplification testing. N Engl J Med 351(8):760–768PubMedCrossRefGoogle Scholar
  33. Strong DM, Nelson K, Pierce M, Stramer SL (2005) Preventing disease transmission by deceased tissue donors by testing blood for viral nucleic acid. Cell Tissue Bank 6:255–262. doi: 10.1007/s10561-005-2834-4 PubMedCrossRefGoogle Scholar
  34. Trotter JF (2008) Infectious disease risk factors of corneal graft donors. Arch Ophthalmol 126(2):235–239. doi: 10.1001/archophthalmol.2007.45 CrossRefGoogle Scholar
  35. Tugwell BD, Patel PR, Williams IT, Hedberg K, Chai F, Nainan OV, Thomas AR, Woll JE, Bell BP, Cieslak PR (2005) Transmission of hepatitis C virus to several organ and tissue recipients from an antibody-negative donor. Ann Intern Med 143:648–654PubMedGoogle Scholar
  36. Wang S, Zinderman C, Wise R, Braun M (2007) Infections and human tissue transplants: review of FDA MedWatch reports 2001–2004. Cell Tissue Bank 8(3):211–219. doi: 10.1007/s10561-007-9034-3 PubMedCrossRefGoogle Scholar
  37. Warren J (2006) BTS stolen body parts scandal generating gruesome headlines, fears of infection; NY grand jury meeting Transplant News, Jan 13Google Scholar
  38. Zou S, Dodd RY, Stramer SL, Strong DM (2004) Tissue Safety Study Group. Probability of viremia with HBV, HCV, HIV, and HTLV among tissue donors in the United States. N Engl J Med 351:751–759. doi: 10.1056/NEJMoa032510 PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Jay A. Fishman
    • 1
  • D. Michael Strong
    • 2
    • 3
  • Matthew J. Kuehnert
    • 4
  1. 1.Transplant Infectious Disease ProgramMassachusetts General HospitalBostonUSA
  2. 2.Department of Orthopaedics and Sports Medicine, School of MedicineUniversity of WashingtonSeattleWashington
  3. 3.Department of Surgery, School of MedicineUniversity of WashingtonSeattleWashington
  4. 4.Centers for Disease Control and PreventionAtlantaGeorgia

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