Bulgarian Bone Marrow Donors Registry—past and future directions
Recently Bulgarian Bone Marrow Donors Registry (BBMDR) has been established and since August 2005 it has been a member of Bone Marrow Donors Worldwide. Currently the number of healthy donors included in the BBMDR is relatively low. All donors included in the BBMDR are typed for HLA-A, -B, -DRB loci. Phylogenetic analysis based on HLA allele frequencies shows that Bulgarians were characterized with closest genetic similarity to Macedonians, Greeks, Romanians, Cretans and Sardinians in comparison to the other European and Mediterranean populations. On the contrary the second largest ethnic minority–the Roma were the closest to the other Roma populations and North Indians. These differences were due to the predominance of alleles and haplotypes that are specific for the Asian and the other Roma populations. These specific genetic profiles in the Bulgarian ethnic minorities justify the need of an adequate representation of minorities in BBMDR. Future directions for BBMDR development are discussed, including an increase of the total number of donors and these for ethnic minorities, as well the enhancement of the level of resolution of the HLA typing for the donors in the registry.
KeywordsBulgarian Bone Marrow Donor Registry Bulgarians HLA alleles HLA haplotypes Roma
- Bodmer J, Cambon-Thomsen A, Hors J, Piaza A, Sanchez-Mazas A (1997) Anthropology Report. Introduction. In: Charron D (ed) Genetic diversity of HLA. Functional and medical implication,vol I. EDK, Paris, pp 269–284Google Scholar
- Clayton J, Lonjou C (1997) Allele and haplotype frequencies for HLA loci in various ethnic groups. In: Charron D (ed) Genetic diversity of HLA. Functional and Medical Implication, vol 1. EDK, Paris, pp 665–820Google Scholar
- Geer L, Terasaki PI, Gjertson D (1998) Gene frequencies and World maps of their distribution. In: Terasaki PI, Gjertson D (eds) HLA 1998. American society for histocompatibility and immunogenetics, Lenexa, pp 327–363Google Scholar
- Terasaki PI, Geer L, Wang X, Gjertson D (1997) Gene frequencies and maps of their distributions. In: Terasaki PI, Gjertson D (eds) HLA 1997. UCLA Tissue Typing Laboratory, Los Angeles, pp 427–460Google Scholar