Cell and Tissue Banking

, Volume 8, Issue 4, pp 267–286

Donor derived malignancy following transplantation: a review

Review Paper

Abstract

Organ and tissue transplant is now the treatment of choice for many end stage diseases. In the recent years, there has been an increasing demand for organs but not a similar increase in the supply leading to a severe shortage of organs for transplant resulted in increasing wait times for recipients. This has resulted in expanded donor criteria to include older donors and donors with mild disease. In spite of implementation of more stringent criteria for donor selection, there continues to be some risk of donor derived malignancy. Malignancy after transplantation can occur in three different ways: (a) de-novo occurrence, (b) recurrence of malignancy, and (c) donor-related malignancy. Donor related malignancy can be either due to direct transmission of tumor or due to tumor arising in cells of donor origin. We will review donor related malignancies following solid organ transplantation and hematopoeitic progenitor cell transplantation. Further, we will briefly review the methods for detection and management of these donor related malignancies.

Keywords

Solid organ transplant Hematopoeitic progenitor cell transplant Stem cell transplant Bone marrow transplant Tumor transmission Donor derived malignancy Donor related malignancy 

Abbreviations

AML

Acute myeloid leukemia

B-HCG

B-human choroinic gonadotrophin

CIS

Carcinoma in situ

CML

Chronic myeloid leukemia

CMV

Cytomegalovirus

CNS

Central nervous system

CTTR

Cincinnati Transplant Tumor Registry

EBV

Epstein Barr Virus

FISH

Fluorescent in situ hybridization

HBV

Hepatitis B virus

HCV

Hepatitis C virus

HHV-8

Human herpes virus 8

HPCT

Hematopoeitic progenitor cell transplantation

HPV

Human papilloma virus

HTLV

Human T-lymphotropic virus

IPTTR

Israel Penn Transplant Tumor Registry

MDS

Myelodysplastic syndrome

NHL

Non-Hodgkin’s lymphoma

OPTN

Organ Procurement and Transplantation Network

PTLD

Post-transplant lymphoproliferative disorder

RFLP

Restriction fragment length polymorphism

SNP

Single nucleotide polymorphism

STR

Repetitive sequence of 2–7 nucleotides long

UNOS

United Network of Organ Sharing

VNTR

Repetitive sequence of 9–45 nucleotides long

WHO

World Health Organization

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  1. 1.Department of Pathology and ImmunologyWashington UniversitySt LouisUSA
  2. 2.Puget Sound Blood CenterSeattleUSA

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