Cell and Tissue Banking

, Volume 8, Issue 4, pp 267–286

Donor derived malignancy following transplantation: a review

Review Paper


Organ and tissue transplant is now the treatment of choice for many end stage diseases. In the recent years, there has been an increasing demand for organs but not a similar increase in the supply leading to a severe shortage of organs for transplant resulted in increasing wait times for recipients. This has resulted in expanded donor criteria to include older donors and donors with mild disease. In spite of implementation of more stringent criteria for donor selection, there continues to be some risk of donor derived malignancy. Malignancy after transplantation can occur in three different ways: (a) de-novo occurrence, (b) recurrence of malignancy, and (c) donor-related malignancy. Donor related malignancy can be either due to direct transmission of tumor or due to tumor arising in cells of donor origin. We will review donor related malignancies following solid organ transplantation and hematopoeitic progenitor cell transplantation. Further, we will briefly review the methods for detection and management of these donor related malignancies.


Solid organ transplant Hematopoeitic progenitor cell transplant Stem cell transplant Bone marrow transplant Tumor transmission Donor derived malignancy Donor related malignancy 



Acute myeloid leukemia


B-human choroinic gonadotrophin


Carcinoma in situ


Chronic myeloid leukemia




Central nervous system


Cincinnati Transplant Tumor Registry


Epstein Barr Virus


Fluorescent in situ hybridization


Hepatitis B virus


Hepatitis C virus


Human herpes virus 8


Hematopoeitic progenitor cell transplantation


Human papilloma virus


Human T-lymphotropic virus


Israel Penn Transplant Tumor Registry


Myelodysplastic syndrome


Non-Hodgkin’s lymphoma


Organ Procurement and Transplantation Network


Post-transplant lymphoproliferative disorder


Restriction fragment length polymorphism


Single nucleotide polymorphism


Repetitive sequence of 2–7 nucleotides long


United Network of Organ Sharing


Repetitive sequence of 9–45 nucleotides long


World Health Organization


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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  1. 1.Department of Pathology and ImmunologyWashington UniversitySt LouisUSA
  2. 2.Puget Sound Blood CenterSeattleUSA

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