Optimal Noise-Immune Genetic Codes
DNA symmetry is used to generate optimal genetic codes whose noise immunity with respect to polarity of amino acids in case of mutations in nucleotides is much greater than immunity of standard codes. Noise immunity of optimal symmetric and non-symmetric genetic codes is analyzed. Databases of genetic diseases are used to show that optimal symmetric code for which symmetry holds in every second case keeps polarity of amino acids at mutations in first and second nucleotides of codon as compared with standard code.
Keywordsgenetic code symmetry in DNA mutations in nucleotides noise immunity amino acid codon
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- 2.A. M. Gupal and I. V. Sergienko, Symmetry in DNA: Methods of Recognition of Discrete Sequences [in Russian], Naukova Dumka, Kyiv (2016).Google Scholar
- 3.M. Ycas, The Biological Code (Frontiers of Biology), American Elsevier Pub. Co. (1969).Google Scholar
- 4.B. M. Mednikov, Biology Axioms [in Russian], Znanie, Moscow (1982).Google Scholar
- 6.A. L. Lehninger, Principles of Biochemistry, Vol. 3 [Russian translation], Mir, Moscow (1985).Google Scholar
- 7.T. A. Brown, Genomes, Garland Sci. (1999).Google Scholar