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Cardiovascular Engineering

, 9:98 | Cite as

Methods for Calculating Coronary Perfusion Pressure During CPR

  • Michael P. OtlewskiEmail author
  • Leslie A. Geddes
  • Michael Pargett
  • Charles F. Babbs
Original Paper

Abstract

Coronary perfusion pressure (CPP) is a major indicator of the effectiveness of cardiopulmonary resuscitation in human and animal research studies, however, methods for calculating CPP differ among research groups. Here we compare the 6 published methods for calculating CPP using the same data set of aortic (Ao) and right atrial (RA) blood pressures. CPP was computed using each of the 6 calculation methods in an anesthetized pig model, instrumented with catheters with Cobe pressure transducers. Aortic and right atrial pressures were recorded continuously during electrically induced ventricular fibrillation and standard AHA CPR. CPP calculated from the same raw data set by the 6 calculation methods ranged from −1 (signifying retrograde blood flow) to 26 mmHg (mean ± SD of 15 ± 11 mmHg). The CPP achieved by standard closed chest CPR is typically reported as 10–20 mmHg. Within a single study the CPP values may be comparable; however, the CPP values for different studies may not be a reliable indicator of the efficacy of a given CPR method. Electronically derived true mean coronary perfusion pressure is arguably the gold standard method for representing coronary perfusion pressure.

Keywords

Cardiopulmonary resuscitation Ventricular fibrillation Coronary perfusion pressure Blood pressure 

Notes

Acknowledgment

Supported in part by National Institutes of Health (NIBIB Grant NGAR2IEBOO1540) and a grant from the Purdue Trask Fund.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Michael P. Otlewski
    • 1
    Email author
  • Leslie A. Geddes
    • 2
  • Michael Pargett
    • 2
  • Charles F. Babbs
    • 3
  1. 1.MED Institute, Inc.West LafayetteUSA
  2. 2.Weldon School of Biomedical EngineeringPurdue UniversityWest LafayetteUSA
  3. 3.Department of Basic Medical SciencesPurdue UniversityWest LafayetteUSA

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