Cardiovascular Drugs and Therapy

, Volume 28, Issue 1, pp 61–71

Can Antihypertensive Medication Interfere with the Vicious Cycle Between Hypertension and Vascular Calcification?

  • Maria I. Pikilidou
  • Maria P. Yavropoulou
  • Angelo Scuteri

DOI: 10.1007/s10557-013-6494-5

Cite this article as:
Pikilidou, M.I., Yavropoulou, M.P. & Scuteri, A. Cardiovasc Drugs Ther (2014) 28: 61. doi:10.1007/s10557-013-6494-5


Vascular calcification is a phenomenon of disturbed calcium deposition, as part of the calcium that is supposed to be deposited to our bones, is lodged to our vessels. There are two forms of vascular calcification, each with a distinct anatomical distribution and clinical relevance, namely the intimal and medial calcification. Studies have demonstrated that hypertension may cause vascular calcification but also that both types of calcification, especially medial, promote arterial rigidity and hence hypertension. Implications of this two-way road are largely unknown as there is no consensus yet on their exact clinical value. However, several antihypertensive medications seem to be able to interfere with the cycle of high blood pressure and vascular calcium deposits. The present review summarizes the up-to-date data regarding the effect of antihypertensive medication on vascular calcification.


Vascular calcification Antihypertensive medication Angiotensin converting enzyme inhibitors Angiotensin receptor blockers Calcium channel blockers 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Maria I. Pikilidou
    • 1
  • Maria P. Yavropoulou
    • 2
  • Angelo Scuteri
    • 3
  1. 1.Hypertension Excellence Center, 1st Department of Internal MedicineAHEPA University HospitalThessalonikiGreece
  2. 2.Division of Endocrinology and Metabolism, 1st Department of Internal MedicineAHEPA University HospitalThessalonikiGreece
  3. 3.Hospital San Raffaele Pisana IRCCSRomeItaly

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