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Cardiovascular Drugs and Therapy

, Volume 25, Issue 1, pp 77–85 | Cite as

Evaluation of the Functional Status Questionnaire in Heart Failure: A Sub-study of the Second Cardiac Insufficiency Bisoprolol Survival Study (CIBIS-II)

  • Siobhan Gallanagh
  • Davide Castagno
  • Ben Wilson
  • Erland Erdmann
  • Faiez Zannad
  • Willem J. Remme
  • José L. Lopez-Sendon
  • Philippe Lechat
  • Ferenc Follath
  • Christer Höglund
  • Viacheslav Mareev
  • Zygmunt Sadowski
  • Ricardo J. Seabra-Gomes
  • Henry J. Dargie
  • John J. V. McMurrayEmail author
Article

Abstract

Aims

We evaluated a generic quality of life (QoL) Functional Status Questionnaire (FSQ), in patients with chronic heart failure (CHF). The FSQ assesses the 3 main dimensions of QoL: physical functioning, mental health and social role. It also includes 6 single item questions about: work status, frequency of social interactions, satisfaction with sexual relationships, days in bed, days with restricted activity and overall satisfaction with health status. The FSQ was compared to the Minnesota Living with Heart Failure questionnaire (MLwHF).

Methods and results

The FSQ was evaluated in a substudy (n = 340) of the second Cardiac Insufficiency Bisoprolol Survival study (CIBIS-II), a placebo-controlled mortality trial. 265 patients (75%) patients completed both questionnaires at 6 months of follow-up. Both questionnaires indicated substantially impaired QoL. The FSQ demonstrated high internal consistency (Cronbach’s α > 0.7 for all items except “social activity” = 0.66) and construct and concurrent validity. After 6 months, the only item on either questionnaire to show a difference between the placebo- and bisoprolol-treatment groups was the single item FSQ question about “days in bed” (p = 0.018 in favour of bisoprolol).

Conclusions

The FSQ performed well in this study, provided additional information to the MLwHF questionnaire and allowed interesting comparisons with other chronic medical conditions. The FSQ may be a useful general QoL instrument for studies in CHF.

Key words

Heart failure Quality of life Functional status questionnaire Minnesota living with heart failure questionnaire 

Supplementary material

10557_2011_6284_MOESM1_ESM.doc (194 kb)
ESM 1 (DOC 194 kb)

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Siobhan Gallanagh
    • 1
  • Davide Castagno
    • 1
    • 2
  • Ben Wilson
    • 1
  • Erland Erdmann
    • 3
  • Faiez Zannad
    • 4
  • Willem J. Remme
    • 5
  • José L. Lopez-Sendon
    • 6
  • Philippe Lechat
    • 7
  • Ferenc Follath
    • 8
  • Christer Höglund
    • 9
  • Viacheslav Mareev
    • 10
  • Zygmunt Sadowski
    • 11
  • Ricardo J. Seabra-Gomes
    • 12
  • Henry J. Dargie
    • 13
  • John J. V. McMurray
    • 1
    Email author
  1. 1.BHF Glasgow Cardiovascular Research CentreUniversity of GlasgowGlasgowUK
  2. 2.Cardiology Unit, Department of Internal MedicineUniversity of TurinTurinItaly
  3. 3.Department III of Internal MedicineUniversity of CologneCologneGermany
  4. 4.University of NancyNancyFrance
  5. 5.Sticares Cardiovascular Research InstituteRhoonNetherlands
  6. 6.Department of CardiologyUniversity Hospital La PazMadridSpain
  7. 7.Pharmacology Department, Pitié-Salpêtrière Hospital, APHP, UPMCParisFrance
  8. 8.University Hospital ZürichZürichSwitzerland
  9. 9.Stockholm Heart CentreStockholmSweden
  10. 10.Myasnikow Institute of CardiologyMoscowRussia
  11. 11.National Institute of CardiologyWarsawPoland
  12. 12.Cardiology DepartmentSanta Cruz HospitalCarnaxidePortugal
  13. 13.Golden Jubilee National Hospital, ClydebankGlasgowUK

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