Cardiovascular Drugs and Therapy

, Volume 23, Issue 6, pp 501–510 | Cite as

Benefits and Difficulties in Measuring HDL Subfractions and Human Paraoxonase-1 Activity During Statin Treatment

  • Mariann Harangi
  • Ildikó Seres
  • János Harangi
  • György Paragh


Dyslipidaemia including decreased high density lipoprotein cholesterol concentration is one of several factors that have been implicated in increased cardiovascular risk. Since their introduction in the 1980s, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have emerged as the one of the best-selling class of medications to date, with numerous trials demonstrating powerful efficacy in preventing cardiovascular diseases. Although statins have been shown to modestly raise or not alter HDL-cholesterol, their effect on HDL subfractions and on HDL-associated enzymes including human paraoxonase-1 (PON1) has not yet been fully explored. This review summarizes the currently availabe data on the effect of statins on HDL subfractions and on PON1 activity with a particular emphasis on the clinical relevance of these effects. Moreover, methodological problems of HDL subfraction and PON1 activity determinations are also discussed.

Key words

Statin High-density lipoprotein subfractions Paraoxonase 


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Mariann Harangi
    • 1
  • Ildikó Seres
    • 1
  • János Harangi
    • 2
  • György Paragh
    • 1
  1. 1.First Department of Medicine, Medical and Health Sciences CenterUniversity of DebrecenDebrecenHungary
  2. 2.Research Laboratory for ChromatographyDebrecenHungary

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