Cardiovascular Drugs and Therapy

, Volume 23, Issue 4, pp 295–299

Increased Levels of 25 Hydroxyvitamin D and 1,25-Dihydroxyvitamin D After Rosuvastatin Treatment: A Novel Pleiotropic Effect of Statins?

  • Bunyamin Yavuz
  • Derun Taner Ertugrul
  • Hicran Cil
  • Naim Ata
  • Kadir Okhan Akin
  • Ahmet Arif Yalcin
  • Metin Kucukazman
  • Kursad Dal
  • Murat Sevket Hokkaomeroglu
  • Burcu Balam Yavuz
  • Emre Tutal
Article

Abstract

Objectives

Low levels of 25-hydroxyvitamin D are associated with higher risk of cardiovascular morbidity and mortality. Large trials demonstrated that statins significantly decrease cardiovascular morbidity and mortality. 7-dehydrocholesterol is the precursor of both cholesterol and vitamin D. The aim of this study was to investigate the possible effect of rosuvastatin on vitamin D metabolism.

Methods

The study was performed in a prospective cohort design. The study group consisted of 91 hyperlipidemic patients who had not been treated with lipid lowering medications. Lipid parameters, 25 hydroxyvitamin-D, 1,25-dihydroxyvitamin D, and bone alkaline phosphatase were obtained at baseline and after 8 weeks of rosuvastatin treatment.

Results

None of the subjects withdrew from the study because of the adverse effects. The mean age was 59.9 ± 12.5 years. The majority of the patients were male (55, 60%). Seventeen patients were diabetic, and 43 patients had systemic hypertension. There was a significant increase in 25-hydroxyvitamin D, from mean 14.0 (range 3.7– 67) to mean 36.3 (range 3.8 –117) ng/ml (p < 0.001), and also an increase of 1,25-dihydroxyvitamin D from mean 22.9 ± 11.2 to 26.6 ± 9.3 pg/dl (p = 0.023). Bone alkaline phosphatase decreased after 8 weeks of rosuvastatin treatment, mean 17.7 (range 2.6–214) to mean 9.5 (range 2.3–19.1) u/l (p < 0.001) rosuvastatin treatment.

Conclusion

This study has shown an effect of rosuvastatin on vitamin D metabolism, with an increase in both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D. This may be an important pleiotropic effect whereby rosuvastatin reduces mortality in patients with coronary artery disease. Further studies are needed to clarify the relationship between statins and vitamin D metabolism.

Key words

25 hydroxyvitamin-D 1,25-dihydroxyvitamin D Rosuvastatin Pleiotropic effect Statin 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Bunyamin Yavuz
    • 1
    • 5
  • Derun Taner Ertugrul
    • 2
  • Hicran Cil
    • 2
  • Naim Ata
    • 2
  • Kadir Okhan Akin
    • 3
  • Ahmet Arif Yalcin
    • 1
  • Metin Kucukazman
    • 2
  • Kursad Dal
    • 2
  • Murat Sevket Hokkaomeroglu
    • 2
  • Burcu Balam Yavuz
    • 4
  • Emre Tutal
    • 2
  1. 1.Kecioren Teaching and Research HospitalDepartment of CardiologyAnkaraTurkey
  2. 2.Kecioren Teaching and Research HospitalDepartment of Internal MedicineAnkaraTurkey
  3. 3.Kecioren Teaching and Research HospitalDepartment of BiochemistryAnkaraTurkey
  4. 4.Hacettepe University Faculty of MedicineDepartment of Internal MedicineAnkaraTurkey
  5. 5.Kecioren Teaching and Research HospitalDepartment of CardiologyKeciorenTurkey

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