Cardiovascular Drugs and Therapy

, Volume 19, Issue 1, pp 9–11 | Cite as

Glucagon Like Peptide-1 is Protective Against Myocardial Ischemia/Reperfusion Injury when Given Either as a Preconditioning Mimetic or at Reperfusion in an Isolated Rat Heart Model

  • Amal K. Bose
  • Mihaela M. Mocanu
  • Richard D. Carr
  • Derek M. YellonEmail author
Short Communication

Key Words

Glucagon like peptide-1 preconditioning reperfusion injury RISK pathway 


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  1. 1.
    Brubaker PL, Drucker DJ. Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology 2004; 145(6):2653–2659.CrossRefPubMedGoogle Scholar
  2. 2.
    Luque MA, Gonzalez N, Marquez L, et al. Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes. J Endocrinol 2002;173(3):465–473.CrossRefPubMedGoogle Scholar
  3. 3.
    Nikolaidis LA, Mankad S, Sokos GG, et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004;109(8):962–965.PubMedGoogle Scholar
  4. 4.
    Huisamen B, Genade S, Lochner A. Glucagon-like peptide-1 (GLP-1) protects the heart against ischaemia by activating glycoclysis. Cardiovasc J S Afr 2004;15(4 Suppl 1): S15.Google Scholar
  5. 5.
    Kavianipour M, Ehlers MR, Malmberg K, et al. Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium. Peptides 2003;24(4):569–578.PubMedGoogle Scholar
  6. 6.
    Bose AK, Mocanu MM, Carr RD, Brand CL, Yellon DM. Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes 2005;54(1):146–151.PubMedGoogle Scholar
  7. 7.
    Hausenloy DJ, Yellon DM. New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the Reperfusion Injury Salvage Kinase(RISK)-pathway. Cardiovasc Res 2004;61(3):448–460.PubMedGoogle Scholar
  8. 8.
    Mocanu MM, Bell RM, Yellon DM. PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning. J Mol Cell Cardiol 2002;34(6):661–668.PubMedGoogle Scholar
  9. 9.
    Acitores A, Gonzalez N, Sancho V, Valverde I, Villanueva-Penacarrillo ML. Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle. J Endocrinol 2004;180(3):389–398.PubMedGoogle Scholar
  10. 10.
    Baines CP, Wang L, Cohen MV, Downey JM. Myocardial protection by insulin is dependent on phospatidylinositol 3-kinase but not protein kinase C or KATP channels in the isolated rabbit heart. Basic Res Cardiol 1999;94(3):188– 198.PubMedGoogle Scholar
  11. 11.
    Jonassen AK, Sack MN, Mjos OD, Yellon DM. Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling. Circ Res 2001;89(12):1191– 1198.PubMedGoogle Scholar

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Amal K. Bose
    • 1
  • Mihaela M. Mocanu
    • 1
  • Richard D. Carr
    • 2
  • Derek M. Yellon
    • 1
    • 3
    Email author
  1. 1.The Hatter Institute and Centre for CardiologyUniversity College London Hospital & Medical SchoolLondonUK
  2. 2.NovoNordisk A/SNovo AlléDenmark
  3. 3.The Hatter Institute and Centre for CardiologyUniversity College London Hospital and Medical SchoolLondon

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