Cardiovascular Drugs and Therapy

, Volume 18, Issue 6, pp 421–431 | Cite as

Pyrroloquinoline Quinone (PQQ) Decreases Myocardial Infarct Size and Improves Cardiac Function in Rat Models of Ischemia and Ischemia/Reperfusion

  • Bo-qing Zhu
  • Hui-zhong Zhou
  • John R Teerlink
  • Joel S Karliner
Basic Pharmacology


As pyrroloquinoline quinone (PQQ) is a redox cofactor in mammals, we asked if it is cardioprotective. Rats were subjected to 2 h of left anterior descending (LAD) coronary artery ligation without reperfusion (model 1, ischemia). In model 2 (ischemia/reperfusion), rats were subjected to 17 or 30 min of LAD occlusion and 2 h of reperfusion. PQQ (15–20 mg/kg) was given i.p., either 30 min before LAD occlusion (Pretreatment) or i.v. at the onset of reperfusion (Treatment). In model 1, PQQ reduced infarct size (10.0 ± 1.5 vs 19.1 ± 2.1%, P < 0.01). In model 2, either PQQ Pretreatment or Treatment also reduced infarct size (18.4 ± 2.3 and 25.6 ± 3.5% vs 38.1 ± 2.6%, P < 0.01). PQQ resulted in higher LV developed pressure and LV (+)dP/dt after 1–2 h of reperfusion (P < 0.05), and fewer ventricular fibrillation episodes. PQQ dose (5–20 mg/kg) was inversely related to infarct size. PQQ reduced myocardial tissue levels of malondialdehyde (MDA), an indicator of lipid peroxidation (316 ± 88 vs 99 ± 14 nmol/g, P < 0.01). PQQ given either as Pretreatment or as Treatment at the onset of reperfusion is highly effective in reducing infarct size and improving cardiac function in a dose-related manner in rat models of ischemia and ischemia/reperfusion. The optimal dose in this study, which exhibited neither renal nor hepatic toxicity, was 15 mg/kg, but lower doses may also be efficacious. We conclude that PQQ, which appears to act as a free radical scavenger in ischemic myocardium, is a highly effective cardioprotective agent.

Key Words

myocardial infarct size ischemia-reperfusion (I/R) pyrroloquinoline quinone (PQQ) hemodynamics 



pyrroloquinoline quinone


analysis of variance


left ventricle


ventricular fibrillation


left anterior descending coronary artery


left ventricular systolic pressure


left ventricular developed pressure




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Copyright information

© Springer Science + Business Media, Inc. 2004

Authors and Affiliations

  • Bo-qing Zhu
    • 1
  • Hui-zhong Zhou
    • 1
  • John R Teerlink
    • 1
  • Joel S Karliner
    • 1
    • 2
  1. 1.Cardiology Section, VA Medical Center; Department of Medicine, and Cardiovascular Research InstituteUniversity of CaliforniaSan Francisco
  2. 2.VA Medical Center, Cardiology 111C5San Francisco

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