Cancer and Metastasis Reviews

, Volume 37, Issue 2–3, pp 203–211 | Cite as

Stress, inflammation, and eicosanoids: an emerging perspective

  • Sujanitha Umamaheswaran
  • Santosh K. Dasari
  • Peiying Yang
  • Susan K. Lutgendorf
  • Anil K. SoodEmail author


Clinical and experimental studies support the notion that adrenergic stimulation and chronic stress affect inflammation, metabolism, and tumor growth. Eicosanoids are also known to heavily influence inflammation while regulating certain stress responses. However, additional work is needed to understand the full extent of interactions between the stress-related pathways and eicosanoids. Here, we review the potential influences that stress, inflammation, and metabolic pathways have on each other, in the context of eicosanoids. Understanding the intricacies of such interactions could provide insights on how systemic metabolic effects mediated by the stress pathways can be translated into therapies for cancer and other diseases.


Eicosanoids PGE2 Inflammation Stress Cancer 


Funding information

This work is supported, in part, by the National Institutes of Health (CA016672, CA109298, CA193249, UH3TR000943, P50 CA217685, P50 CA083639, R35 CA209904), Ovarian Cancer Research Fund, Inc. (Program Project Development Grant), the Blanton-Davis Ovarian Cancer Research Program, the American Cancer Society Research Professor Award, and the Frank McGraw Memorial Chair in Cancer Research (A.K.S.).


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Sujanitha Umamaheswaran
    • 1
    • 2
  • Santosh K. Dasari
    • 1
  • Peiying Yang
    • 3
  • Susan K. Lutgendorf
    • 4
    • 5
    • 6
    • 7
  • Anil K. Sood
    • 1
    • 2
    • 8
    Email author
  1. 1.Department of Gynecologic Oncology and Reproductive MedicineThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Department of Cancer BiologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  3. 3.Department of Palliative, Rehabilitation and Integrative MedicineThe University of Texas MD Anderson Cancer CenterHoustonUSA
  4. 4.Department of Psychological and Brain SciencesUniversity of IowaIowa CityUSA
  5. 5.Department of Obstetrics and GynecologyUniversity of IowaIowa CityUSA
  6. 6.Department of UrologyUniversity of IowaIowa CityUSA
  7. 7.Holden Comprehensive Cancer CenterUniversity of IowaIowa CityUSA
  8. 8.Center for RNA Interference and Non-coding RNAThe University of Texas MD Anderson Cancer CenterHoustonUSA

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