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Cancer and Metastasis Reviews

, Volume 33, Issue 4, pp 1043–1057 | Cite as

New approaches to selectively target cancer-associated matrix metalloproteinase activity

  • Marilena Tauro
  • Jeremy McGuire
  • Conor C. Lynch
Non-Thematic Review

Abstract

Heightened matrix metalloproteinase (MMP) activity has been noted in the context of the tumor microenvironment for many years, and causal roles for MMPs have been defined across the spectrum of cancer progression. This is primarily due to the ability of the MMPs to process extracellular matrix (ECM) components and to regulate the bioavailability/activity of a large repertoire of cytokines and growth factors. These characteristics made MMPs an attractive target for therapeutic intervention but notably clinical trials performed in the 1990s did not fulfill the promise of preclinical studies. The reason for the failure of early MMP inhibitor (MMPI) clinical trials that are multifold but arguably principal among them was the inability of early MMP-based inhibitors to selectively target individual MMPs and to distinguish between MMPs and other members of the metzincin family. In the decades that have followed the MMP inhibitor trials, innovations in chemical design, antibody-based strategies, and nanotechnologies have greatly enhanced our ability to specifically target and measure the activity of MMPs. These advances provide us with the opportunity to generate new lines of highly selective MMPIs that will not only extend the overall survival of cancer patients, but will also afford us the ability to utilize heightened MMP activity in the tumor microenvironment as a means by which to deliver MMPIs or MMP activatable prodrugs.

Keywords

Matrix metalloproteinase Extracellular matrix Activity-based protein probes Tumor microenvironment Cancer progression and metastasis 

Notes

Acknowledgments

We gratefully acknowledge the National Cancer Institute (RO1CA143094). We would also like to thank Barbara Fingleton at Vanderbilt University for her evaluation and critique of the manuscript.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Marilena Tauro
    • 1
  • Jeremy McGuire
    • 1
  • Conor C. Lynch
    • 1
  1. 1.Departments of Tumor BiologyMoffitt Cancer Center and Research InstituteTampaUSA

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