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Cancer and Metastasis Reviews

, Volume 33, Issue 2–3, pp 809–822 | Cite as

Antibody-based imaging strategies for cancer

  • Jason M. Warram
  • Esther de Boer
  • Anna G. Sorace
  • Thomas K. Chung
  • Hyunki Kim
  • Rick G. Pleijhuis
  • Gooitzen M. van Dam
  • Eben L. Rosenthal
CLINICAL

Abstract

Although mainly developed for preclinical research and therapeutic use, antibodies have high antigen specificity, which can be used as a courier to selectively deliver a diagnostic probe or therapeutic agent to cancer. It is generally accepted that the optimal antigen for imaging will depend on both the expression in the tumor relative to normal tissue and the homogeneity of expression throughout the tumor mass and between patients. For the purpose of diagnostic imaging, novel antibodies can be developed to target antigens for disease detection, or current FDA-approved antibodies can be repurposed with the covalent addition of an imaging probe. Reuse of therapeutic antibodies for diagnostic purposes reduces translational costs since the safety profile of the antibody is well defined and the agent is already available under conditions suitable for human use. In this review, we will explore a wide range of antibodies and imaging modalities that are being translated to the clinic for cancer identification and surgical treatment.

Keywords

Antibody Imaging Cancer 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Jason M. Warram
    • 1
  • Esther de Boer
    • 1
  • Anna G. Sorace
    • 3
  • Thomas K. Chung
    • 1
  • Hyunki Kim
    • 2
  • Rick G. Pleijhuis
    • 4
  • Gooitzen M. van Dam
    • 4
  • Eben L. Rosenthal
    • 1
    • 5
  1. 1.Department of SurgeryUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Department of RadiologyUniversity of Alabama at BirminghamBirminghamUSA
  3. 3.Department of Radiology & Radiological SciencesVanderbilt UniversityNashvilleUSA
  4. 4.Department of Surgery, University Medical Center GroningenUniversity of GroningenGroningenThe Netherlands
  5. 5.Division of OtolaryngologyBirminghamUSA

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