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Cancer and Metastasis Reviews

, Volume 33, Issue 2–3, pp 673–693 | Cite as

Emerging technology: applications of Raman spectroscopy for prostate cancer

  • Rachel E. Kast
  • Stephanie C. Tucker
  • Kevin Killian
  • Micaela Trexler
  • Kenneth V. Honn
  • Gregory W. AunerEmail author
Article

Abstract

There is a need in prostate cancer diagnostics and research for a label-free imaging methodology that is nondestructive, rapid, objective, and uninfluenced by water. Raman spectroscopy provides a molecular signature, which can be scaled from micron-level regions of interest in cells to macroscopic areas of tissue. It can be used for applications ranging from in vivo or in vitro diagnostics to basic science laboratory testing. This work describes the fundamentals of Raman spectroscopy and complementary techniques including surface enhanced Raman scattering, resonance Raman spectroscopy, coherent anti-Stokes Raman spectroscopy, confocal Raman spectroscopy, stimulated Raman scattering, and spatially offset Raman spectroscopy. Clinical applications of Raman spectroscopy to prostate cancer will be discussed, including screening, biopsy, margin assessment, and monitoring of treatment efficacy. Laboratory applications including cell identification, culture monitoring, therapeutics development, and live imaging of cellular processes are discussed. Potential future avenues of research are described, with emphasis on multiplexing Raman spectroscopy with other modalities.

Keywords

Raman spectroscopy Prostate cancer Diagnostics Biomarkers Therapeutics 

Notes

Acknowledgments

This work was funded, in part by the Strauss TEAMS Endowed Chair, the Wayne State University Department of Surgery, and the Henry Ford Health System.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Rachel E. Kast
    • 1
  • Stephanie C. Tucker
    • 2
    • 3
  • Kevin Killian
    • 1
  • Micaela Trexler
    • 1
  • Kenneth V. Honn
    • 2
    • 3
  • Gregory W. Auner
    • 1
    • 3
    • 4
    Email author
  1. 1.Smart Sensors and Integrated Microsystems Laboratories, Department of Electrical and Computer EngineeringWayne State UniversityDetroitUSA
  2. 2.Bioactive Lipids Research Program (BLRP), Department of PathologyWayne State University School of MedicineDetroitUSA
  3. 3.Karmanos Cancer InstituteDetroitUSA
  4. 4.Department of SurgeryWayne State University School of MedicineDetroitUSA

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