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Cancer and Metastasis Reviews

, Volume 31, Issue 3–4, pp 419–428 | Cite as

Genomics screens for metastasis genes

  • Jinchun YanEmail author
  • Qihong HuangEmail author
Article

Abstract

Metastasis is responsible for most cancer mortality. The process of metastasis is complex, requiring the coordinated expression and fine regulation of many genes in multiple pathways in both the tumor and host tissues. Identification and characterization of the genetic programs that regulate metastasis is critical to understanding the metastatic process and discovering molecular targets for the prevention and treatment of metastasis. Genomic approaches and functional genomic analyses can systemically discover metastasis genes. In this review, we summarize the genetic tools and methods that have been used to identify and characterize the genes that play critical roles in metastasis.

Keywords

Metastasis Genomic screen Functional genomics Next-generation sequencing 

Notes

Acknowledgments

We thank Ms. Lisa Bain and Gail Hauptfuhrer for editorial assistance. Because of page limitations, it is impossible to cite all the literatures. The authors apologize to colleagues whose valuable work, while uncited in this review, has enormous impact on the field. Q.H. is supported by R01CA148759 from NCI, W.W. Smith Foundation, Edward Mallinckrodt Jr. Foundation, and Breast Cancer Alliance.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.University of Washington Medical CenterSeattleUSA
  2. 2.The Wistar InstitutePhiladelphiaUSA

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