Mast cell: insight into remodeling a tumor microenvironment
- 850 Downloads
Mast cells are of paramount importance to allergies, pathogen immune responses during infections, and angiogenesis, as well as innate and adaptive immune regulations. Beyond all these roles, mast cells are now more and more being recognized as modulators of tumor microenvironment. Notwithstanding mounting evidences of mast cell accumulation in tumors, their exact role in tumor microenvironment is still incompletely understood. In this review, we discuss the significant role of mast cells in the remodeling of tumor microenvironment by either releasing various factors after activation or interacting with other cells within tumor and, as a result, the possible role of mast cell in cancer invasion and metastasis. We also discuss recent findings that mast cells actively release microparticles, which account for the transfer of membrane-type receptor signal and regulatory molecules such as microRNAs to tumor cells and immune cells. These findings on mast cells provide further insights into the complexity of tumor microenvironment remodeling.
KeywordsMast cell Tumor microenvironment Mediators Stromal cells Microparticles
The authors thank Dr. Yonghong Wan of McMaster University (Canada) and Dr. Yan Su of The University of Maryland (USA) for their helpful discussion and assistance in editing this article.
This work was supported by the National Natural Science Foundation of China (30871020), Funds for International Cooperation and Exchange of the National Natural Science Foundation of China (30911120482), the Program for New Century Excellent Talents in University (NCET-08-0219), Special Research Foundation for Universities affiliated with China Ministry of Education (Z2009005), Important National Science and Technology Specific Projects (2009ZX09301-014), Scientific Research Foundation of Wuhan City Human Resource for Returned Scholars.
- 27.Matsushima, H., Yamada, N., Matsue, H., & Shimada, S. (2004). TLR3-, TLR7-, and TLR9-mediated production of proinflammatory cytokines and chemokines from murine connective tissue type skin-derived mast cells but not from bone marrow-derived mast cells. Journal of Immunology, 173, 531–541.Google Scholar
- 29.Piccinini, A. M., & Midwood, K. S. (2010). DAMPening Inflammation by Modulating TLR Signalling. Mediators of Inflammation, 2010.Google Scholar
- 33.Smiley, S. T., King, J. A., & Hancock, W. W. (2001). Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. Journal of Immunology, 167, 2887–2894.Google Scholar
- 46.Tsuji, K., Nakahata, T., Takagi, M., Kobayashi, T., Ishiguro, A., Kikuchi, T., et al. (1990). Effects of interleukin-3 and interleukin-4 on the development of "connective tissue-type" mast cells: interleukin-3 supports their survival and interleukin-4 triggers and supports their proliferation synergistically with interleukin-3. Blood, 75, 421–427.PubMedGoogle Scholar
- 48.Finotto, S., Buerke, M., Lingnau, K., Schmitt, E., Galle, P. R., & Neurath, M. F. (2001). Local administration of antisense phosphorothioate oligonucleotides to the c-kit ligand, stem cell factor, suppresses airway inflammation and IL-4 production in a murine model of asthma. The Journal of Allergy and Clinical Immunology, 107, 279–286.PubMedCrossRefGoogle Scholar
- 53.Blatner, N. R., Bonertz, A., Beckhove, P., Cheon, E. C., Krantz, S. B., Strouch, M., et al. (2010). In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction. Proceedings of the National Academy of Sciences of the United States of America, 107, 6430–6435.PubMedCrossRefGoogle Scholar
- 64.Pelosi, G., Barisella, M., Pasini, F., Leon, M. E., Veronesi, G., Spaggiari, L., et al. (2004). CD117 immunoreactivity in stage I adenocarcinoma and squamous cell carcinoma of the lung: relevance to prognosis in a subset of adenocarcinoma patients. Modern Pathology, 17, 711–721.PubMedCrossRefGoogle Scholar