Cancer and Metastasis Reviews

, Volume 28, Issue 1–2, pp 177–183

Tumor stroma derived biomarkers in cancer


DOI: 10.1007/s10555-008-9175-2

Cite this article as:
Sund, M. & Kalluri, R. Cancer Metastasis Rev (2009) 28: 177. doi:10.1007/s10555-008-9175-2


In recent years the importance of the tumor stroma for the development, promotion and invasion of cancer is becoming increasingly clear. Besides a malignantly transformed cancer cell, tumors also contains many other cell types, including endothelial cells, fibroblasts and cells of the immune system. These cells together with the cancer cells produce the sum extracellular matrix (ECM) of the tumor. The ECM and the non-malignant cells of the tumor are defined as the “tumor stroma”. Just as the malignant cell itself can be the source of substances that can be used as biomarkers of cancer, the tumor stroma contains factors that potentially can be used as biomarkers when treating patients with cancer. In this review we will discuss the role of the tumor stroma as a source of new cancer biomarkers. This concept highlights a novel view of cancer and treats them as organized organs. Additionally, this further stresses the importance of including factors related to the tumor stroma into the diagnostic and therapeutic equation of cancer.


Cancer Biomarker Stroma Collagen 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Division for Matrix Biology CLS 11087Beth Israel Deaconess Medical Center and Harvard Medical SchoolBostonUSA
  2. 2.Department of SurgeryUmea UniversityUmeaSweden

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