Cancer and Metastasis Reviews

, 25:373

Pro-angiogenic cytokines and their role in tumor angiogenesis


DOI: 10.1007/s10555-006-9011-5

Cite this article as:
Neufeld, G. & Kessler, O. Cancer Metastasis Rev (2006) 25: 373. doi:10.1007/s10555-006-9011-5


The development of solid tumors depends upon an adequate supply of blood. This can be achieved by way of co-option of preexisting blood vessels and by the induction of angiogenesis. During the past 30 years, tumor angiogenesis had been found to play a crucial role in the progression of solid tumors. Tumor angiogenesis was found to be induced by a variety of pro-angiogenic cytokines of which the best characterized is vascular endothelial growth factor (VEGF). Indeed, the first FDA approved anti-angiogenic drug for the treatment of cancer is AvastinTM, a neutralizing antibdy directed against VEGF. This review focuses on cytokines which have been reported to induce tumor angiogenesis.


Tumor progression Tumorigenesis Review Angiogenesis Lymphangiogenesis cytokines Metastasis Tumor angiogenesis 

Copyright information

© Springer Science + Business Media, LLC 2006

Authors and Affiliations

  1. 1.Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, TechnionIsrael Institute of TechnologyHaifaIsrael

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