Cancer and Metastasis Reviews

, 25:409 | Cite as

TNF-α in promotion and progression of cancer

  • Frances Balkwill


Tumour necrosis factor alpha is a member of the TNF/TNFR cytokine superfamily. In common with other family members, TNF-α is involved in maintenance and homeostasis of the immune system, inflammation and host defence. However, there is a ‘dark side’ to this powerful cytokine; it is now clear that, especially in middle and old age, TNF-α is involved in pathological processes such as chronic inflammation, autoimmunity and, in apparent contradiction to its name, malignant disease. This article will discuss the involvement of TNF-α in the inflammatory network that contributes to all stages of the malignant process, and consider the possibility that TNF-α may be a target for cancer therapy.


TNF-α Inflammation Cytokine Chemokine 


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© Springer Science + Business Media, LLC 2006

Authors and Affiliations

  1. 1.Centre for Translational Oncology, Institute of Cancer and the CR-UK Clinical CentreBarts and The London, Queen Mary’s School of Medicine and DentistryLondonUK

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